3D biodegradable shape changing composite scaffold with programmable porous structures for bone engineering

被引:7
作者
Chen, Xiaohu [2 ]
Huang, Zuoxun [2 ]
Yang, Qing [2 ]
Zeng, Xiyang [2 ]
Bai, Ruqing [3 ]
Wang, Li [1 ,2 ]
机构
[1] Chengdu Med Coll, Sch Big Hlth & Intelligent Engn, Dept Biomed Engn, Chengdu 610500, Peoples R China
[2] Chengdu Univ Technol, Coll Mat Chem & Chem Engn, Chengdu 610059, Sichuan, Peoples R China
[3] Chongqing Univ, State Key Lab Mech Transmission, Chongqing 400044, Peoples R China
关键词
3D scaffolds; hydroxyapatite; polyurethane; shape changing behavior; biocompatibility; THERMOPLASTIC POLYURETHANE; TISSUE; POLYCAPROLACTONE; WETTABILITY; FABRICATION; STRENGTH; BEHAVIOR;
D O I
10.1088/1748-605X/aca133
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This study developed a biodegradable composite porous polyurethane scaffold based on polycaprolactone and polyethylene glycol by sequential in-situ foaming salt leaching and freeze-drying process with responsive shape changing performance. Biomineral hydroxyapatite (HA) was introduced into the polyurethane matrix as inorganic fillers. Infrared spectroscopy results proved a successful synthesis, scanning electron microscopy showed that the scaffold's porosity decreased with the addition of HA while the average pore size increased. X-ray diffraction and differential scanning calorimetry showed that the addition of HA lowered the melting point of the scaffold, resulting in a transition temperature close to the human body temperature. From the bending experiments, it could be demonstrated that PUHA20 has excellent shape memory performance with shape fixity ratio >98.9% and shape recovery ratio >96.2%. Interestingly, the shape-changing capacity could be influenced by the porous structures with variation of HA content. The shape recovery speed was further accelerated when the material was immersed in phosphate buffered saline at 37 degrees C. Additionally, in vitro mineralization experiments showed that the scaffold incorporating HA had good osteoconductivity, and implantation assessment proved that scaffolds had good in vivo biocompatibility. This scaffold is a promising candidate for implantation of bone defects.
引用
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页数:11
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