Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model
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作者:
Kotanska, Magdalena
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Jagiellonian Univ, Dept Pharmacol Screening, Med Coll, 9 Med St, PL-30688 Krakow, PolandJagiellonian Univ, Dept Pharmacol Screening, Med Coll, 9 Med St, PL-30688 Krakow, Poland
Kotanska, Magdalena
[1
]
Mika, Kamil
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Jagiellonian Univ, Dept Pharmacol Screening, Med Coll, 9 Med St, PL-30688 Krakow, PolandJagiellonian Univ, Dept Pharmacol Screening, Med Coll, 9 Med St, PL-30688 Krakow, Poland
Mika, Kamil
[1
]
Salaciak, Kinga
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Jagiellonian Univ, Fac Pharm, Dept Pharmacodynam, Med Coll, Krakow, PolandJagiellonian Univ, Dept Pharmacol Screening, Med Coll, 9 Med St, PL-30688 Krakow, Poland
Purpose: Histamine H-3 receptor ligands may have antidepressant and anxiolytic effects. They can also cornpensate for metabolic disorders, which affect glucose or triglyceride levels. In previous studies, we have shown that pitolisant, a histamine H-3 receptor antagonist/inverse agonist and al receptor agonist, prevented the development of certain metabolic and depressive-like disorders in mice that have been treated chronically with olanzapine. Methods: As a continuation of our previous experiments, this study aimed to investigate the antidepressant- and anxiolytic-like activity of pitolisant in mice using the corticosterone-induced depression model. The forced swim and the elevated plus maze tests were used as behavioral endpoints. We also studied the effect pitolisant had on the level of acetoacetic acid in the urine as well as the glucose tolerance and body weight of the mice that had been administered corticosterone. Results: Pitolisant (10 mg/kg b.w.) did not prevent depressive-like behavior in mice during the chronic corticosterone administration but did counteract anxiety-like behavior, whilst fluoxetine (10 mg/kg) was shown to protect the mice from both of these behaviors. None of the treatments that were used in the study showed an effect on the locomotor activity of the mice. Pitolisant did not prevent an increase in acetoacetic acid levels in the urine, nor did it improve glucose tolerance in the tested mice. Conclusion: Although literature data indicates that there is significant potential for finding an antidepressant and anti-diabetic drug among the histamine H-3 and sigma 1 receptor ligands, in our study, pitolisant was shown to only slightly compensate for corticosterone-induced abnormalities. However, further research will be required to study pitolisant's anxiolytic-like activity.
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Tao, Yanlin
Shen, Wei
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Shen, Wei
Zhou, Houyuan
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Zhou, Houyuan
Li, Zikang
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Li, Zikang
Pi, Ting
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Chenggong Hosp, Kunming Yanan Hosp, Maanshan, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Pi, Ting
Wu, Hui
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Wu, Hui
Shi, Hailian
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Shi, Hailian
Huang, Fei
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Huang, Fei
Wu, Xiaojun
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Shanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Key Lab Standardizat Chinese Med,Inst Chinese Mat, Shanghai Key Lab Compound Chinese Med, Minist Educ,MOE,Innovat Ctr Basic Med Res Qi Blood, Shanghai 201203, Peoples R China
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Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R ChinaChangchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
Li, Huitao
Li, Jiannan
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Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R ChinaChangchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
Li, Jiannan
Zhang, Tong
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Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R ChinaChangchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
Zhang, Tong
Xie, Xiaoyan
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Changchun Univ Chinese Med, Dept Pharm, Affiliated Clin Hosp 3, Changchun 130117, Peoples R ChinaChangchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
Xie, Xiaoyan
Gong, Jiyu
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Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R ChinaChangchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China
机构:
Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Ago, Yukio
Yano, Koji
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Yano, Koji
Araki, Ryota
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Araki, Ryota
Hiramatsu, Naoki
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Hiramatsu, Naoki
Kita, Yuki
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Kita, Yuki
Kawasaki, Toshiyuki
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Kobe MI R&D Ctr, Ctr Mol Imaging Sci, Funct Probe Res Lab,RIKEN, Chuo Ku, Kobe, Hyogo 6500047, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Kawasaki, Toshiyuki
Onoe, Hirotaka
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Kobe MI R&D Ctr, Ctr Mol Imaging Sci, Funct Probe Res Lab,RIKEN, Chuo Ku, Kobe, Hyogo 6500047, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Onoe, Hirotaka
Chaki, Shigeyuki
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Taisho Pharmaceut Co Ltd, Mol Funct & Pharmacol Labs, Kita Ku, Saitama 3319530, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Chaki, Shigeyuki
Nakazato, Atsuro
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Taisho Pharmaceut Co Ltd, R&D Headquarters Pharmaceut Operat, Strateg Planning Drug Discovery, Kita Ku, Saitama 3319530, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Nakazato, Atsuro
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Hashimoto, Hitoshi
Baba, Akemichi
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan
Hyogo Univ Hlth Sci, Chuo Ku, Kobe, Hyogo 6508530, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Baba, Akemichi
Takuma, Kazuhiro
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Takuma, Kazuhiro
Matsuda, Toshio
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Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
Chiba Univ, Hamamatsu Univ Sch Med, Kanazawa Univ, Osaka Univ,United Grad Sch Child Dev, Suita, Osaka 5650871, Japan
Univ Fukui, Suita, Osaka 5650871, JapanOsaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan
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Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Zhang, Bo
Li, Yu
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Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Li, Yu
Liu, Miao
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Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100029, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Liu, Miao
Duan, Xiao-Hua
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Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100029, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Duan, Xiao-Hua
Hu, Kai-Li
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Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Hu, Kai-Li
Li, Li-Na
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Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100029, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Li, Li-Na
Yu, Xue
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Beijing Univ Chinese Med, Sch Chinese Med, Beijing 100029, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
Yu, Xue
Chang, Hong-Sheng
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Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R ChinaBeijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102488, Peoples R China
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Univ Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, BrazilUniv Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, Brazil
da Silva Souza, Suene Vanessa
da Rosa, Priscila Batista
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Univ Fed Santa Catarina, Biol Sci Ctr, Biochem Dept, BR-88040900 Florianopolis, SC, BrazilUniv Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, Brazil
da Rosa, Priscila Batista
Neis, Vivian Binder
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Univ Fed Santa Catarina, Biol Sci Ctr, Biochem Dept, BR-88040900 Florianopolis, SC, BrazilUniv Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, Brazil
Neis, Vivian Binder
Moreira, Julia Dubois
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Univ Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, BrazilUniv Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, Brazil
Moreira, Julia Dubois
Rodrigues, Ana Lucia S.
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Univ Fed Santa Catarina, Biol Sci Ctr, Biochem Dept, BR-88040900 Florianopolis, SC, BrazilUniv Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, Brazil
Rodrigues, Ana Lucia S.
Moretti, Morgana
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Univ Fed Santa Catarina, Biol Sci Ctr, Biochem Dept, BR-88040900 Florianopolis, SC, BrazilUniv Fed Santa Catarina, Hlth Sci Ctr, Grad Program Nutr, BR-88040900 Florianopolis, SC, Brazil