Oral delivery of anticancer drugs III: formulation using drug delivery systems

被引：78

作者：

Mazzaferro, Silvia ^{[1
]}

Bouchemal, Kawthar ^{[1
]}

Ponchel, Gilles ^{[1
]}

机构：

[1] Univ Paris 11, Fac Pharm, UMR CNRS 8612, Inst Galien Paris Sud, F-92296 Chatenay Malabry, France

来源：

DRUG DISCOVERY TODAY | 2013年 / 18卷 / 1-2期

关键词：

SOLID LIPID NANOPARTICLES; CACO-2 CELL MONOLAYERS; POORLY SOLUBLE DRUGS; IN-VITRO EVALUATION; MULTIDRUG-RESISTANCE; POLY(AMIDOAMINE) DENDRIMERS; GASTROINTESTINAL ABSORPTION; MICROEMULSION FORMULATION; POLYMERIZED LIPOSOMES; ENHANCED ABSORPTION;

D O I：

10.1016/j.drudis.2012.08.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the past few years, the growth of nanometric size drug delivery systems (DDS) has burst into challenging innovations enabling real progresses to achieve oral delivery of anticancer drugs. DDS, such as polymeric nanoparticles, micelles, dendrimers and lipid-based formulations enable physico-chemical properties of cytotoxic agents to be improved and oral bioavailability to be enhanced. In this review we highlight current DDS used for the oral delivery of anticancer drugs.

引用

页码：99 / 104

页数：6

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