The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

被引：94
作者：
Liu, Zhong-Min [1 ]
Wang, Kun-Peng [2 ,3 ]
Ma, Jilin [2 ,4 ]
Zheng, Song Guo [1 ,2 ]
机构：
[1] Tongji Univ, Sch Med, East Hosp, Res Ctr Translat Med, Shanghai 200092, Peoples R China
[2] Penn State Hershey Coll Med, Div Rheumatol, Hershey, PA USA
[3] Nanjing Med Univ, Affiliated Hosp 1, Div Liver Surg, Nanjing, Jiangsu, Peoples R China
[4] Zhejiang Prov Tradit Chinese Med & Western Med Ho, Div Rheumatol Immunol & Nephrol, Hangzhou, Zhejiang, Peoples R China
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2015年 / 12卷 / 05期
基金：
中国国家自然科学基金;
关键词：
atRA; autoimmune diseases; Foxp3; Treg cells; TGF-BETA; CUTTING EDGE; TH17; GENERATION; EXPANSION; AUTOIMMUNE; EXPRESSION; CD4(+); INDUCTION; IL-2;
D O I：
10.1038/cmi.2014.133
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role in their differentiation and function. Foxp3(+) Treg cells are consisted of naturally occurring, thymus-derived Treg (nTreg) and peripheral-induced Treg (iTreg) cells that may have different functional characteristics or synergistic roles. All-trans retinoic acid (atRA), a vitamin A metabolite, regulates a wide range of biological processes, including cell differentiation and proliferation. Recent studies demonstrated that atRA also regulates the differentiation of T helper (Th) cells and Treg cells. Moreover, atRA also sustains nTreg stability under inflammatory conditions. In this review, we summarize the significant progress of our understanding of the role(s) and mechanisms of atRA in Treg biology.
引用
收藏
页码：553 / 557
页数：5
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