Procedural and shunt-related complications and mortality of the transjugular intrahepatic portosystemic shunt (TIPSS)

Background The implantation of a transjugular intrahepatic portosystemic shunt (TIPSS) is a complex angiographic procedure performed in patients with end-stage liver disease. Numerous case reports and narrative reviews have been published so far; however, studies systematically investigating procedural and shunt-related complications are lacking. Aim To systematically investigate complications and mortality occurring during the index hospital stay and the early (4-week) period after TIPSS implantation. Methods The study includes 389 patients who received a TIPSS implantation between 2004 and 2014. Data were obtained from the clinical records and technical reports of the TIPSS implantation. Results During the index hospital stay, procedure-related complications occurred in 42 patients (10.8%) with intraperitoneal bleeding in 8 patients (2.1%) and infections in 14 patients (3.6%). Shunt-and disease-related complications consisted of hepatic encephalopathy (1-year incidence 29%), nonprocedural infections (8.7%) and acute hepatic decompensation (4.1%). Nine patients (2.3%) died during the index hospital stay from procedure-related (two patients, 0.5%), shunt-related (four patients, 1%) or diseaserelated causes (three patients, 0.8%). 23 patients (5.9%) died during 4 weeks after TIPSS implantation. The 1-year probability of survival was 67.7% and was negatively associated with severe hepatic encephalopathy and acute hepatic decompensation. Conclusions Except hepatic encephalopathy, severe procedure-and shunt-related complications are rare and early mortality is low.