Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant sterol consumption

被引：8

作者：

Mackay, Dylan S. ^{[1
,2
]}

Eck, Peter K. ^{[2
]}

Rideout, Todd C. ^{[3
]}

Baer, David J. ^{[4
]}

Jones, Peter J. H. ^{[1
,2
,5
]}

机构：

[1] Univ Manitoba, Richardson Ctr Funct Foods & Nutraceut, Winnipeg, MB R3T 6C5, Canada

[2] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada

[3] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14214 USA

[4] ARS, USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA

[5] Univ Manitoba, Dept Food Sci, Winnipeg, MB R3T 6C5, Canada

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2015年 / 40卷 / 08期

基金：

加拿大健康研究院;

关键词：

plant sterols; phytosterols; nutrigenetics; triglycerides; CETP; METABOLIC SYNDROME PATIENTS; SERUM-LIPIDS; TRIACYLGLYCEROL;

D O I：

10.1139/apnm-2015-0039

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Recent work suggests that plant sterol (PS) consumption may lower triglyceride (TG) concentrations; however, human clinical trial evidence is inconsistent. We associated SNP r5882 in cholesteryl ester transfer protein with changes in TG concentrations following PS consumption (2 g/day for 4 weeks) in a dual-centre, single-blind, randomized, crossover trial. TG concentrations were lowered in homozygotes for the minor G-allele of rs5882 (-0.46 +/- 0.13 mmol/L, p = 0.002, n = 10); there was no effect in the A-allele carriers.

引用

页码：846 / 849

页数：4

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