Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: Its significance in cartilage repair and replacement

被引：40

作者：

Freemont, AJ ^{[1
]}

Hoyland, J ^{[1
]}

机构：

[1] Univ Manchester, Regenerat Med Res Grp, DLRM, Manchester M13 9PT, Lancs, England

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 2006年 / 57卷 / 01期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会; 澳大利亚研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

cartilage; fibrocartilage; injury; repair;

D O I：

10.1016/j.ejrad.2005.08.008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Cartilage repair is a major goal of modem tissue engineering. To produce novel engineered implants requires a knowledge of the basic biology of the tissues that are to be replaced or reproduced. Hyaline articular cartilage and meniscal fibrocartilage are two tissues that have excited attention because of the frequency with which they are damaged. A basic strategy is to re-engineer these tissues ex vivo by stimulating stem cells to differentiate into the cells of the mature tissue capable of producing an intact functional matrix. In this brief review, the sources of cells for tissue engineering cartilage and the culture conditions that have promoted differentiation are discussed within the context of natural cartilage repair. In particular, the role of cell density, cytokines, load, matrices and oxygen tension are discussed. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：32 / 36

页数：5

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