Development of PMMA-Mon-CNT bone cement with superior mechanical properties and favorable biological properties for use in bone-defect treatment

被引：55

作者：

Pahlevanzadeh, F. ^{[1
]}

Bakhsheshi-Rad, H. R. ^{[2
,3
]}

Ismail, A. F. ^{[3
]}

Aziz, M. ^{[3
]}

Chen, X. B. ^{[4
]}

机构：

[1] Islamic Azad Univ, Dept Tissue Engn, Najafabad Branch, Najafabad, Iran

[2] Islamic Azad Univ, Adv Mat Res Ctr, Dept Mat Engn, Najafabad Branch, Najafabad, Iran

[3] Univ Teknol Malaysia, Adv Membrane Technol Res Ctr AMTEC, Johor Baharu 81310, Johor, Malaysia

[4] Univ Saskatchewan, Coll Engn, Dept Mech Engn, Saskatoon, SK, Canada

来源：

MATERIALS LETTERS | 2019年 / 240卷

关键词：

PMMA bone cement; Monticellite; Carbon nanotubes; Bioactivity; Mechanical properties; COMPOSITES;

D O I：

10.1016/j.matlet.2018.12.049

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Treatment of bone defects requires materials or bone cement with superior mechanical properties and favorable biological properties, but this remains unachievable to date. To address this issue, the present study aimed to synthesize and characterize a novel poly(methyl methacrylate) (PMMA) bone cement containing monticellite (Mon) and carbon nanotubes (CNTs) for bone defect treatment. Considerably better mechanical properties were noted in the PMMA-Mon-CNT vs. PMMA and PMMA-Mon bone cements due to the unique resistance of CNTs to crack formation and propagation. Favorable bioactivity was also found in the bone cements containing Mon and CNTs, whereas the PMMA bone cement presented poor bioactivity. Specifically, the incorporation of Mon and CNTs into the PMMA matrix promoted the attachment of MG63 cells compared to the PMMA cement. Thus, the PMMA-Mon-CNT bone cements developed are good potential candidates for filling bone defects in orthopedic surgeries. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：9 / 12

页数：4