Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes

被引：64

作者：

Fuyuno, Yoko ^{[1
]}

Uchi, Hiroshi ^{[1
]}

Yasumatsu, Mao ^{[2
]}

Morino-Koga, Saori ^{[3
]}

Tanaka, Yuka ^{[2
]}

Mitoma, Chikage ^{[1
,2
]}

Furue, Masutaka ^{[1
,2
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[2] Kyushu Univ Hosp, Res & Clin Ctr Yusho & Dioxin, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Div Stat,Ctr Cohort Studies, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2018年 / 2018卷

关键词：

ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; EMERGING ROLE; NITRIC-OXIDE; SKIN; CELLS; PSORIASIS; SYSTEM; TISSUE;

D O I：

10.1155/2018/9524657

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a) pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress.

引用

页数：9

共 39 条

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