Inhibition of human melanoma cell replication using protein transduction technology with a uracil-DNA glycosylase inhibitor

被引：1
作者：
Ariza, ME
Pedersen, I
Williams, MV
机构：
[1] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[2] Burnham Inst, La Jolla, CA 92037 USA
[3] Biota Inc, Carlsbad, CA USA
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2005年 / 2卷 / 02期
关键词：
uracil-DNA glycosylase; uracil-DNA glycosylase inhibitor; protein transduction; melanoma;
D O I：
10.2174/1570180053175179
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We demonstrated that the uracil-DNA glycosylase inhibitor, when delivered to human melanoma cells using protein transduction technology, resulted in a dose and time dependent inhibition of uracil-DNA glycosylase (UNG) and this inhibited cell proliferation. These results suggest that a novel class of inhibitors specifically targeting UNG can be developed as potential anti-cancer agents.
引用
收藏
页码：92 / 96
页数：5
相关论文
共 39 条
  • [1] Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs
    Albert, ML
    Sauter, B
    Bhardwaj, N
    [J]. NATURE, 1998, 392 (6671) : 86 - 89
  • [2] Interleukin-2: Clinical applications
    Atkins, MB
    [J]. SEMINARS IN ONCOLOGY, 2002, 29 (03) : 12 - 17
  • [3] SECONDARY STRUCTURE OF URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
    BALASUBRAMANIAN, S
    BEGER, RD
    BENNETT, SE
    MOSBAUGH, DW
    BOLTON, PH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) : 296 - 303
  • [4] CUTANEOUS MELANOMA - PROGNOSIS AND TREATMENT RESULTS WORLDWIDE
    BALCH, CM
    [J]. SEMINARS IN SURGICAL ONCOLOGY, 1992, 8 (06): : 400 - 414
  • [5] TERTIARY STRUCTURE OF URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
    BEGER, RD
    BALASUBRAMANIAN, S
    BENNETT, SE
    MOSBAUGH, DW
    BOLTON, PH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16840 - 16847
  • [6] Role of MED1 (MBD4) gene in DNA repair and human cancer
    Bellacosa, A
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2001, 187 (02) : 137 - 144
  • [7] Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes:: Clinical and immunologic findings
    Belli, F
    Testori, A
    Rivoltini, L
    Maio, M
    Andreola, G
    Sertoli, MR
    Gallino, G
    Piris, A
    Cattelan, A
    Lazzari, I
    Carrabba, M
    Scita, G
    Santantonio, C
    Pilla, L
    Tragni, G
    Lombardo, C
    Arienti, F
    Marchianò, A
    Queirolo, P
    Bertolini, F
    Cova, A
    Lamaj, E
    Ascani, L
    Camerini, R
    Corsi, M
    Cascinelli, N
    Lewis, JJ
    Srivastava, P
    Parmiani, G
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (20) : 4169 - 4180
  • [8] Bellone M, 1997, J IMMUNOL, V159, P5391
  • [9] BENNETT SE, 1993, J BIOL CHEM, V268, P26879
  • [10] BENNETT SE, 1992, J BIOL CHEM, V267, P22512
1234