Basics of the virology of HIV-1 and its replication

被引：89
作者：
Sierra, S
Kupfer, B
Kaiser, R
机构：
[1] Univ Cologne, Inst Virol, D-50935 Cologne, Germany
[2] Univ Bonn, Inst Med Microbiol & Immunol, D-53105 Bonn, Germany
来源：
JOURNAL OF CLINICAL VIROLOGY | 2005年 / 34卷 / 04期
关键词：
HIV-1; replication cycle; viral persistence; antiretroviral therapy; immune response; receptors;
D O I：
10.1016/j.jcv.2005.09.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral treatment and vaccination. Since the first isolation of HIV-1 in cell culture, thousands Of publications dealing with HIV and/or AIDS per year were released. In this review we give a basic overview of the virology of HIV-1 including the functions of the different HIV-1 proteins required for effective viral replication. Moreover, we summarize the interactive processes between HIV-1 and its target cells. Finally, the HIV-1 specific immune response and the current status of antiretroviral therapy are briefly described in this review. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：233 / 244
页数：12
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