Basics of the virology of HIV-1 and its replication

被引：89

作者：

Sierra, S

Kupfer, B

Kaiser, R

机构：

[1] Univ Cologne, Inst Virol, D-50935 Cologne, Germany

[2] Univ Bonn, Inst Med Microbiol & Immunol, D-53105 Bonn, Germany

来源：

JOURNAL OF CLINICAL VIROLOGY | 2005年 / 34卷 / 04期

关键词：

HIV-1; replication cycle; viral persistence; antiretroviral therapy; immune response; receptors;

D O I：

10.1016/j.jcv.2005.09.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral treatment and vaccination. Since the first isolation of HIV-1 in cell culture, thousands Of publications dealing with HIV and/or AIDS per year were released. In this review we give a basic overview of the virology of HIV-1 including the functions of the different HIV-1 proteins required for effective viral replication. Moreover, we summarize the interactive processes between HIV-1 and its target cells. Finally, the HIV-1 specific immune response and the current status of antiretroviral therapy are briefly described in this review. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：233 / 244

页数：12

相关论文

共 185 条

[111] Reasons for modification and discontinuation of antiretrovirals: results from a single treatment centre [J].

Mocroft, A ;

Youle, M ;

Moore, A ;

Sabin, CA ;

Madge, S ;

Lepri, AC ;

Tyrer, M ;

Chaloner, C ;

Wilson, D ;

Loveday, C ;

Johnson, MA ;

Phillips, AN .

AIDS, 2001, 15 (02) :185-194

[112] Insights into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral naive patients [J].

Monforte, AD ;

Lepri, AC ;

Rezza, G ;

Pezzotti, P ;

Antinori, A ;

Phillips, AN ;

Angarano, G ;

Colangeli, V ;

De Luca, A ;

Ippolito, G ;

Caggese, L ;

Soscia, F ;

Filice, G ;

Gritti, F ;

Narciso, P ;

Tirelli, U ;

Moroni, M .

AIDS, 2000, 14 (05) :499-507

[113]

MONTAGNIER L, 1994, ENCY VIROLOGY, V2, P674

[114] IMMUNOLOGICAL INCOMPETENCE IN AIDS [J].

MOORE, JP ;

BLANC, DF .

AIDS, 1991, 5 (04) :455-456

[115]

MOORE JP, 1993, VIRAL FUSION MECHANI, P233

[116] Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies [J].

Nabatov, AA ;

Pollakis, G ;

Linnemann, T ;

Kliphius, A ;

Chalaby, MIM ;

Paxton, WA .

JOURNAL OF VIROLOGY, 2004, 78 (01) :524-530

[117] A CCR2-V641 polymorphism affects stability of CCR2A isoform [J].

Nakayama, EE ;

Tanaka, Y ;

Nagai, Y ;

Iwamoto, A ;

Shioda, T .

AIDS, 2004, 18 (05) :729-738

[118] 3-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1 [J].

NAVIA, MA ;

FITZGERALD, PMD ;

MCKEEVER, BM ;

LEU, CT ;

HEIMBACH, JC ;

HERBER, WK ;

SIGAL, IS ;

DARKE, PL ;

SPRINGER, JP .

NATURE, 1989, 337 (6208) :615-620

[119] Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts [J].

Nguyen, DH ;

Hildreth, JEK .

JOURNAL OF VIROLOGY, 2000, 74 (07) :3264-3272

[120] HIV entry inhibitors in clinical development [J].

O'Hara, BM ;

Olson, WC .

CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (05) :523-528

← 7 8 9 10 11 12 13 14 15 16 →