Basics of the virology of HIV-1 and its replication

被引：89

作者：

Sierra, S

Kupfer, B

Kaiser, R

机构：

[1] Univ Cologne, Inst Virol, D-50935 Cologne, Germany

[2] Univ Bonn, Inst Med Microbiol & Immunol, D-53105 Bonn, Germany

来源：

JOURNAL OF CLINICAL VIROLOGY | 2005年 / 34卷 / 04期

关键词：

HIV-1; replication cycle; viral persistence; antiretroviral therapy; immune response; receptors;

D O I：

10.1016/j.jcv.2005.09.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus is undoubtedly the causative agent of AIDS. The understanding of HIV-1 pathogenesis is essentiell to develop and maintain antiretroviral treatment and vaccination. Since the first isolation of HIV-1 in cell culture, thousands Of publications dealing with HIV and/or AIDS per year were released. In this review we give a basic overview of the virology of HIV-1 including the functions of the different HIV-1 proteins required for effective viral replication. Moreover, we summarize the interactive processes between HIV-1 and its target cells. Finally, the HIV-1 specific immune response and the current status of antiretroviral therapy are briefly described in this review. (c) 2005 Elsevier B.V. All rights reserved.

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页码：233 / 244

页数：12

相关论文

共 185 条

[1] CELLULAR LATENCY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED INDIVIDUALS WITH HIGH CD4 LEVELS CAN BE DETECTED BY THE PRESENCE OF PROMOTER-PROXIMAL TRANSCRIPTS [J].

ADAMS, M ;

SHARMEEN, L ;

KIMPTON, J ;

ROMEO, JM ;

GARCIA, JV ;

PETERLIN, BM ;

GROUDINE, M ;

EMERMAN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3862-3866

[2] NEF STIMULATES HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROVIRAL DNA-SYNTHESIS [J].

AIKEN, C ;

TRONO, D .

JOURNAL OF VIROLOGY, 1995, 69 (08) :5048-5056

[3] CELLULAR PROTEINS BOUND TO IMMUNODEFICIENCY VIRUSES - IMPLICATIONS FOR PATHOGENESIS AND VACCINES [J].

ARTHUR, LO ;

BESS, JW ;

SOWDER, RC ;

BENVENISTE, RE ;

MANN, DL ;

CHERMANN, JC ;

HENDERSON, LE .

SCIENCE, 1992, 258 (5090) :1935-1938

[4]

ASJO B, 1986, LANCET, V2, P660

[5] Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines [J].

Bannert, N ;

Craig, S ;

Farzan, M ;

Sogah, D ;

Santo, NV ;

Choe, H ;

Sodroski, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (11) :1661-1673

[6] Highly active antiretroviral therapy: Current state of the art, new agents and their pharmacological interactions useful for improving therapeutic outcome [J].

Barbaro, G ;

Scozzafava, A ;

Mastrolorenzo, A ;

Supuran, CT .

CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (14) :1805-1843

[7] FUNCTIONAL ROLES FOR THE TATA PROMOTER AND ENHANCERS IN BASAL AND TAT-INDUCED EXPRESSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT [J].

BERKHOUT, B ;

JEANG, KT .

JOURNAL OF VIROLOGY, 1992, 66 (01) :139-149

[8] Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons [J].

Bernard, NF ;

Yannakis, CM ;

Lee, JS ;

Tsoukas, CM .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (03) :538-547

[9] Biphasic decay of latently infected CD4+ T cells in acute human immunodeficiency virus type 1 infection [J].

Blankson, JN ;

Finzi, D ;

Pierson, TC ;

Sabundayo, BP ;

Chadwick, K ;

Margolick, JB ;

Quinn, TC ;

Siliciano, RF .

JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (06) :1636-1642

[10] Cell surface CD4 inhibits HTV-1 particle release by interfering with Vpu activity [J].

Bour, S ;

Perrin, C ;

Strebel, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (47) :33800-33806

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