New Potential Targets to Modulate Neutrophil Function in Inflammation

被引：14

作者：

Burgos, R. A. ^{[1
]}

Hidalgo, M. A. ^{[1
]}

Figueroa, C. D. ^{[2
]}

Conejeros, I. ^{[1
]}

Hancke, J. L. ^{[1
]}

机构：

[1] Univ Austral Chile, Mol Pharmacol Lab, Inst Pharmacol, Fac Vet Sci, Valdivia, Chile

[2] Univ Austral Chile, Lab Cellular Pathol, Inst Anat Histol & Pathol, Fac Med, Valdivia, Chile

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 02期

关键词：

Neutrophil; drugs; innate immunity; inflammation; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; LEUKOTRIENE B-4 RECEPTOR; OPERATED CA2+ ENTRY; OBSTRUCTIVE PULMONARY-DISEASE; HISTONE DEACETYLASE ACTIVITY; PDE4 INHIBITOR ROFLUMILAST; INDUCED LUNG INFLAMMATION; GLUCOCORTICOID-RECEPTOR; IN-VIVO;

D O I：

10.2174/138955709787316092

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The importance of neutrophils in human disease such as rheumatoid arthritis, asthma, adult respiratory distress syndrome, and COPD has prompted the search for drugs capable to slow down neutrophil-dependent inflammation, without interference with innate immune responses. In this review, we summarize new potential drugs targets against neutrophils mediated inflammatory responses.

引用

页码：153 / 168

页数：16

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