Interdependence of histamine and methylhistamine kinetics: modelling and simulation approach

被引：7

作者：

Belic, A

Grabnar, I

Karba, R

Mrhar, A

Irman-Florjanc, T

Primozic, S

机构：

[1] Univ Ljubljana, Fac Elect Engn, Ljubljana, Slovenia

[2] Univ Ljubljana, Fac Pharm, Ljubljana, Slovenia

[3] Univ Ljubljana, Fac Med, Dept Pharmacol, Ljubljana, Slovenia

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 1999年 / 29卷 / 06期

关键词：

histamine; methylhistamine; pharmacokinetics; control loop; modelling; compartment models;

D O I：

10.1016/S0010-4825(99)00017-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the article a model of histamine kinetics is described. A motivation of this project was to investigate the hypothesis that methylhistamine may be a marker of histamine appearance in plasma. A model has been made to support the hypothesis. Since metabolic and transport pathways of histamine and methylhistamine are complex and not very well known, the relationship between histamine and methylhistamine should be elucidated by mathematical modelling. From experimental data and the information in the literature, a nonlinear and time-varying four-compartment model is proposed. Extensive release of histamine from mast cells when methylhistamine is injected, is modelled as histamine to methylhistamine ratio control loop. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：361 / 375

页数：15

共 19 条

[1]

[Anonymous], 1992, MODERN CONTROL SYSTE

[2]

BABE KS, 1996, GOODMAN GILMANS PHAR, P583

[3]

Cellier F.E., 1991, Continuous System Modeling

[4]

COBELLI C, 1985, P ID SYST PAR EST YO, P1409

[5]

Eykhoff P., 1974, System Identification

[6]

Gibaldi M. P., 1982, PHARMACOKINETICS

[7]

Godfrey K., 1983, Compartmental models and their application

[8]

GODFREY KR, 1995, P ID SYST PAR EST YO, P89

[9]

IRMANFLORJANC T, 1993, AGENTS ACTIONS, V38, P76

[10]

IRMANFLORJANC T, 1991, AGENTS ACTIONS, V33, P33

← 1 2 →