Emerging Strategies of Engineering and Tracking Dendritic Cells for Cancer Immunotherapy

被引：3

作者：

Gao, Yu ^{[1
,2
]}

Wang, Zhixuan ^{[3
]}

Cui, Ying ^{[3
]}

Xu, Miaomiao ^{[3
]}

Weng, Lixing ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China

[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China

[3] Nanjing Univ Posts & Telecommun, Sch Geog & Biol Informat, Nanjing 210023, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 6卷 / 01期

关键词：

dendritic cells; cancer immunotherapy; cancer vaccine; noninvasive imaging; cell tracking; UP-CONVERSION NANOPARTICLES; EPIDERMAL LANGERHANS CELLS; IN-VIVO ENRICHMENT; KINASE; LIGAND; T-CELLS; CROSS-PRESENTATION; STEADY-STATE; ARTIFICIAL-INTELLIGENCE; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE;

D O I：

10.1021/acsabm.2c00790

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Dendritic cells (DCs), a kind of specialized immune cells, play key roles in antitumor immune response and promotion of innate and adaptive immune responses. Recently, many strategies have been developed to utilize DCs in cancer therapy, such as delivering antigens and adjuvants to DCs and using scaffold to recruit and activate DCs. Here we outline how different DC subsets influence antitumor immunity, summarize the FDA approved vaccines and cancer vaccines under clinical trials, discuss the strategies for engineering DCs and noninvasive tracking of DCs to improve antitumor immunotherapy, and reveal the potential of artificial neural networks for the design of DC based vaccines.

引用

页码：24 / 43

页数：20