Emerging Strategies of Engineering and Tracking Dendritic Cells for Cancer Immunotherapy

被引：3

作者：

Gao, Yu ^{[1
,2
]}

Wang, Zhixuan ^{[3
]}

Cui, Ying ^{[3
]}

Xu, Miaomiao ^{[3
]}

Weng, Lixing ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China

[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat IAM, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China

[3] Nanjing Univ Posts & Telecommun, Sch Geog & Biol Informat, Nanjing 210023, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 6卷 / 01期

关键词：

dendritic cells; cancer immunotherapy; cancer vaccine; noninvasive imaging; cell tracking; UP-CONVERSION NANOPARTICLES; EPIDERMAL LANGERHANS CELLS; IN-VIVO ENRICHMENT; KINASE; LIGAND; T-CELLS; CROSS-PRESENTATION; STEADY-STATE; ARTIFICIAL-INTELLIGENCE; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE;

D O I：

10.1021/acsabm.2c00790

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Dendritic cells (DCs), a kind of specialized immune cells, play key roles in antitumor immune response and promotion of innate and adaptive immune responses. Recently, many strategies have been developed to utilize DCs in cancer therapy, such as delivering antigens and adjuvants to DCs and using scaffold to recruit and activate DCs. Here we outline how different DC subsets influence antitumor immunity, summarize the FDA approved vaccines and cancer vaccines under clinical trials, discuss the strategies for engineering DCs and noninvasive tracking of DCs to improve antitumor immunotherapy, and reveal the potential of artificial neural networks for the design of DC based vaccines.

引用

页码：24 / 43

页数：20

共 50 条

[21] Engineered dendritic cells-derived extracellular vesicles for cancer immunotherapy [J].

Coelho, Margarida Oliveira ;

Quintas, Sofia Torres ;

Sarmento, Bruno ;

De Wever, Olivier ;

Castro, Flavia .

JOURNAL OF CONTROLLED RELEASE, 2025, 381

[22] The clinical application of cancer immunotherapy based on naturally circulating dendritic cells [J].

Bol, Kalijn F. ;

Schreibelt, Gerty ;

Rabold, Katrin ;

Wculek, Stefanie K. ;

Schwarze, Julia Katharina ;

Dzionek, Andrzej ;

Teijeira, Alvaro ;

Kandalaft, Lana E. ;

Romero, Pedro ;

Coukos, George ;

Neyns, Bart ;

Sancho, David ;

Melero, Ignacio ;

de Vries, I. Jolanda M. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7

[23] Insights Into Dendritic Cells in Cancer Immunotherapy: From Bench to Clinical Applications [J].

Salah, Ahmed ;

Wang, Hao ;

Li, Yanqin ;

Ji, Meng ;

Ou, Wen-Bin ;

Qi, Nianmin ;

Wu, Yuehong .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9

[24] The tumor microenvironment and dendritic cells: Developers of pioneering strategies in colorectal cancer immunotherapy? [J].

Ghorbaninezhad, Farid ;

Nour, Mina Afrashteh ;

Farzam, Omid Rahbar ;

Saeedi, Hossein ;

Vanan, Ahmad Ghorbani ;

Bakhshivand, Mohammad ;

Jafarlou, Mahdi ;

Hatami-sadr, Amirhossein ;

Baradaran, Behzad .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2025, 1880 (02)

[25] Regulatory dendritic cells New targets for cancer immunotherapy [J].

Shurin, Michael R. ;

Naiditch, Hiam ;

Zhong, Hua ;

Shurin, Galina V. .

CANCER BIOLOGY & THERAPY, 2011, 11 (11) :988-992

[26] Cell Tracking in Cancer Immunotherapy [J].

Perrin, Justine ;

Capitao, Marisa ;

Mougin-Degraef, Marie ;

Guerard, Francois ;

Faivre-Chauvet, Alain ;

Rbah-Vidal, Latifa ;

Gaschet, Joelle ;

Guilloux, Yannick ;

Kraeber-Bodere, Francoise ;

Cherel, Michel ;

Barbet, Jacques .

FRONTIERS IN MEDICINE, 2020, 7

[27] Immunotherapy with dendritic cells for prostate cancer [J].

Thomas-Kaskel, Anna-Katharina ;

Waller, Cornelius F. ;

Schultze-Seemann, Wolfgang ;

Veelken, Hendrik .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (03) :467-473

[28] Dendritic cells as vectors for immunotherapy of cancer [J].

Paczesny, S ;

Ueno, H ;

Fay, J ;

Banchereau, J ;

Palucka, AK .

SEMINARS IN CANCER BIOLOGY, 2003, 13 (06) :439-447

[29] Immunotherapy of cancer using dendritic cells [J].

Morse, MA ;

Lyerly, HK .

CYTOKINES CELLULAR & MOLECULAR THERAPY, 1998, 4 (01) :35-44

[30] Editorial: Emerging engineering approaches in cancer immunotherapy [J].

Xu, Jialu ;

Ming, Xin ;

Min, Yuanzeng ;

Wang, Chao .

FRONTIERS IN ONCOLOGY, 2022, 12

← 1 2 3 4 5 →