NLRP3 as a potentially novel biomarker for the management of osteoarthritis

被引：186
作者：
McAllister, M. J. [1 ]
Chemaly, M. [1 ]
Eakin, A. J. [1 ]
Gibson, D. S. [1 ]
McGilligan, V. E. [1 ]
机构：
[1] Ulster Univ, Altnagelvin Hosp, Northern Ireland Ctr Stratified Med, Glenshane Rd, Coleraine, Londonderry, North Ireland
来源：
OSTEOARTHRITIS AND CARTILAGE | 2018年 / 26卷 / 05期
基金：
英国惠康基金;
关键词：
Osteoarthritis; NLRP3; Inflammasome; Biomarker; Inflammation; GLUCOSYL-GALACTOSYL-PYRIDINOLINE; KNEE OSTEOARTHRITIS; INFLAMMASOME ACTIVATION; RADIOGRAPHIC PROGRESSION; DIAGNOSTIC PERFORMANCE; ARTICULAR CHONDROCYTES; SYNOVIAL INFLAMMATION; BIOCHEMICAL MARKERS; HAND OSTEOARTHRITIS; INSULIN-RESISTANCE;
D O I：
10.1016/j.joca.2018.02.901
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Osteoarthritis (OA) was previously thought of as 'wear and tear' as humans age, however there is increasing evidence to support an inflammatory theory. The nucleotide-binding and oligomerization domain-like receptor containing protein 3 (NLRP3) inflammasome has been implicated in the pathogenesis of a number of arthritic disorders, producing proinflammatory cytokines and degradative enzymes such as Interleukin-1 beta (IL-1 beta), Tumour necrosis factor alpha (TNF-alpha) and Matrix metalloproteinase-3 (MMP-3) which drive cartilage degeneration and synovial inflammation. This review aims to summarise the evidence of NLRP3 involvement in OA. Currently, treatment options focus on management of the disease and to date there is no cure. The development of novel biomarkers for OA could improve diagnosis, treatment and management. Importantly, this review provides detail on the involvement of the NLRP3 inflammasome in OA pathology and how its members could act as potential biomarkers to assist clinical decisions. (C) 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：612 / 619
页数：8
相关论文
共 88 条
[1]   Clinical and radiographic distribution of structural damage in erosive and nonerosive hand osteoarthritis [J].
Addimanda, Olga ;
Mancarella, Luana ;
Dolzani, Paolo ;
Punzi, Leonardo ;
Fioravanti, Antonella ;
Pignotti, Elettra ;
Meliconi, Riccardo .
ARTHRITIS CARE & RESEARCH, 2012, 64 (07) :1046-1053
[2]  
Aigner T, 1999, ARTHRITIS RHEUM, V42, P1443, DOI 10.1002/1529-0131(199907)42:7<1443::AID-ANR18>3.0.CO
[3]  
2-A
[4]   Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model [J].
Almonte-Becerril, M. ;
Navarro-Garcia, F. ;
Gonzalez-Robles, A. ;
Vega-Lopez, M. A. ;
Lavalle, C. ;
Kouri, J. B. .
APOPTOSIS, 2010, 15 (05) :631-638
[5]  
[Anonymous], 2017, GBD COMP DAT VIS
[6]   Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].
Atkinson, AJ ;
Colburn, WA ;
DeGruttola, VG ;
DeMets, DL ;
Downing, GJ ;
Hoth, DF ;
Oates, JA ;
Peck, CC ;
Schooley, RT ;
Spilker, BA ;
Woodcock, J ;
Zeger, SL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95
[7]   Prognostic biomarkers in osteoarthritis [J].
Attur, Mukundan ;
Krasnokutsky-Samuels, Svetlana ;
Samuels, Jonathan ;
Abramson, Steven B. .
CURRENT OPINION IN RHEUMATOLOGY, 2013, 25 (01) :136-144
[8]   Osteoarthritis: an update with relevance for clinical practice [J].
Bijlsma, Johannes W. J. ;
Berenbaum, Francis ;
Lafeber, Foris P. J. G. .
LANCET, 2011, 377 (9783) :2115-2126
[9]   Stress-Induced Cartilage Degradation Does Not Depend on the NLRP3 Inflammasome in Human Osteoarthritis and Mouse Models [J].
Bougault, Carole ;
Gosset, Marjolaine ;
Houard, Xavier ;
Salvat, Colette ;
Godmann, Lars ;
Pap, Thomas ;
Jacques, Claire ;
Berenbaum, Francis .
ARTHRITIS AND RHEUMATISM, 2012, 64 (12) :3972-3981
[10]   Molecular mechanisms involved in inflammasome activation [J].
Bryant, Clare ;
Fitzgerald, Katherine A. .
TRENDS IN CELL BIOLOGY, 2009, 19 (09) :455-464
123456789