New Insights into the Role of Sphingolipid Metabolism in Melanoma

被引：20

作者：

Carrie, Lorry ^{[1
]}

Virazels, Mathieu ^{[1
]}

Dufau, Carine ^{[1
]}

Montfort, Anne ^{[1
]}

Levade, Thierry ^{[1
,2
]}

Segui, Bruno ^{[1
]}

Andrieu-Abadie, Nathalie ^{[1
]}

机构：

[1] Univ Toulouse III Paul Sabatier, Ctr Rech Cancerol Toulouse, Equipe Labellisee Fdn ARC, Univ Federale Toulouse Midi Pyrenees,Inserm 1037, 2 Ave Hubert Curien,CS 53717, F-31037 Toulouse 1, France

[2] CHU, Lab Biochim Metab, F-31059 Toulouse, France

来源：

CELLS | 2020年 / 9卷 / 09期

关键词：

cancer; ceramide; gangliosides; immunotherapy; metastasis; phenotype switching; sphingosine; 1-phosphate; GROWTH-FACTOR-BETA; MEMORY T-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; NEURONOPATHIC GAUCHER-DISEASE; PROTEIN-COUPLED RECEPTOR; SPHINGOSINE KINASE 1; MALIGNANT-MELANOMA; DOWN-REGULATION; ACID CERAMIDASE; PHASE-III;

D O I：

10.3390/cells9091967

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic patients remains uncertain mainly because of resistances. Better understanding the mechanisms responsible for melanoma progression is therefore essential to uncover new therapeutic targets. Interestingly, the sphingolipid metabolism is dysregulated in melanoma and is associated with melanoma progression and resistance to treatment. This review summarises the impact of the sphingolipid metabolism on melanoma from the initiation to metastatic dissemination with emphasis on melanoma plasticity, immune responses and resistance to treatments.

引用

页码：1 / 29

页数：28