Photoredox-catalyzed hydroxyfluoroalkylation of alkene with simple fluoroalkyl iodides

被引：13
作者：
Geng, Xiaoyu [1 ]
Lin, Fengguirong [1 ]
Wang, Xiaoyang [1 ]
Jiao, Ning [1 ,2 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China
[2] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2018年 / 355卷
基金：
中国国家自然科学基金;
关键词：
Oxygenation; Dioxygen; Photoredox-catalysis; Alkenes; Hydroxyfluoroalkylation; Difunctionalization; HIGHLY EFFICIENT; MOLECULAR-OXYGEN; OLEFINS; OXYTRIFLUOROMETHYLATION; FLUORINE; TRIFLUOROMETHYLATION; DERIVATIVES; ALKYNES; ACCESS;
D O I：
10.1016/j.jphotochem.2017.09.031
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Hydroxyfluoroalkylation of simple alkenes is presented with readily available fluoroalkyl iodides by the virtue of photoredox catalysis in good efficiency and regioselectivity. This chemistry features mild condition, simple operation and good substrate scope. A variety of styrenes as well as non-activated aliphatic alkenes can be selectively transformed to beta-fluoroalkylated alcohols. Preliminary mechanistic studies indicated a radical process with fluoroalkyl radicals which were generated from rethictive quenching of photocatalytic circle. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：194 / 201
页数：8
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