Neurodevelopmental, educational and behavioral outcome at 8 years after neonatal ECMO: a nationwide multicenter study

被引:102
作者
Madderom, Marlous J. [1 ,2 ]
Reuser, Jolanda J. C. M. [3 ]
Utens, Elisabeth M. W. J. [4 ]
van Rosmalen, Joost [5 ]
Raets, Marlou [6 ]
Govaert, Paul [6 ]
Steiner, Katerina [7 ]
Gischler, Saskia J. [1 ,2 ]
Tibboel, Dick [1 ,2 ]
van Heijst, Arno F. J. [7 ]
IJsselstijn, Hanneke [1 ,2 ]
机构
[1] Sophia Childrens Univ Hosp, NL-3015 GJ Rotterdam, Netherlands
[2] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Paediat Surg, NL-3015 GJ Rotterdam, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Psychol, NL-6525 ED Nijmegen, Netherlands
[4] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat Psychol, NL-3015 GJ Rotterdam, Netherlands
[5] Erasmus MC, Dept Biostat, Rotterdam, Netherlands
[6] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Neonatol, NL-3015 GJ Rotterdam, Netherlands
[7] Radboud Univ Nijmegen, Med Ctr, Dept Neonatol, NL-6525 ED Nijmegen, Netherlands
关键词
Extracorporeal membrane oxygenation; Congenital diaphragmatic hernia; Neurodevelopmental outcome; Intelligence; Behavior; EXTRACORPOREAL MEMBRANE-OXYGENATION; COLLABORATIVE RANDOMIZED-TRIAL; FOLLOW-UP; SCHOOL-AGE; INTELLIGENCE; SURVIVORS; CHILDREN;
D O I
10.1007/s00134-013-2973-1
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Reporting neurodevelopmental outcome of 8-year-old children treated with neonatal extracorporeal membrane oxygenation (ECMO). In a follow-up study in 135 8-year-old children who received neonatal ECMO between 1996 and 2001 we assessed intelligence (Revised Amsterdam Intelligence Test), concentration (Bourdon-Vos test), eye-hand coordination (Developmental Test of Visual-Motor Integration) and behavior (Child Behavior Checklist and Teacher Report Form). Intelligence fell within normal range (mean IQ 99.9, SD 17.7, n = 125) with 91 % of the children following regular education. Significantly more children attended special education (9 %) or received extra support in regular education (39 %) compared with normative data. Slower working speed (chi(2) = 132.36, p < 0.001) and less accuracy (chi(2) = 12.90, p < 0.001) were found on the Bourdon-Vos test (n = 123) compared with normative data. Eye-hand coordination fell within the normal range (mean 97.6, SD 14.3, n = 126); children with congenital diaphragmatic hernia scored lowest but still normally (mean 91.0, SD 16.4, n = 28). Mothers (n = 117) indicated more somatic and attention behavior problems; teachers (n = 115) indicated more somatic, social, thought, aggression and total problems compared with normative data. Mothers indicated more somatic problems than teachers (p = 0.003); teachers reported more attention problems than mothers (p = 0.036; n = 111). Eight-year-old children treated with neonatal ECMO fall in the normal range of intelligence with problems with concentration and behavior. Long-term follow-up for children treated with neonatal ECMO should focus on early detection of (subtle) learning deficits.
引用
收藏
页码:1584 / 1593
页数:10
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