Circulating microRNAs

被引：23

作者：

Makarova, J. A. ^{[1
,2
]}

Shkurnikov, M. U. ^{[2
,3
]}

Turchinovich, A. A. ^{[4
]}

Tonevitsky, A. G. ^{[3
]}

Grigoriev, A. I. ^{[5
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

[2] Sci Res Ctr Bioclinicum, Moscow 115088, Russia

[3] Minist Hlth Russian Federat, Branch Natl Med Res Radiol Ctr, Hertsen Moscow Oncol Res Inst, Moscow 125284, Russia

[4] German Canc Res Ctr, Mol Epidemiol Grp, D-69120 Heidelberg, Germany

[5] Russian Acad Sci, Inst Biomed Problems, Moscow 123007, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2015年 / 80卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

miRNA; exosomes; biomarkers; noncoding RNA; cancer; EXTRACELLULAR VESICLES; PLASMA MICRORNAS; MESSENGER-RNAS; INTERCELLULAR COMMUNICATION; NONCODING RNAS; CANCER; EXOSOMES; BIOMARKERS; BIOGENESIS; MIRNAS;

D O I：

10.1134/S0006297915090035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The detection of miRNAs in plasma and other body fluids opened up a fascinating possibility that animal noncoding RNAs can act as extracellular signaling molecules. In this review, we discuss recent progress in the field including the ability of miRNAs to participate in intercellular communication in vitro and in vivo, and the application of circulating miRNAs as diagnostic markers of a wide range of diseases. Special attention is paid to the relevance of the development and unification of current techniques for isolation of circulating miRNAs.

引用

页码：1117 / 1126

页数：10

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