Characterization of modified cellulose (MC)/poly (vinyl alcohol) electrospun nanofibers for bone tissue engineering

被引:19
作者
Chahal, Sugandha [1 ]
Hussain, Fathima Shahitha Jahir [1 ]
Yusoff, Mashitah Mohd [1 ]
机构
[1] Univ Malaysia Pahang, Fac Ind Sci & Technol, Kuantan 26070, Pahang, Malaysia
来源
MALAYSIAN TECHNICAL UNIVERSITIES CONFERENCE ON ENGINEERING & TECHNOLOGY 2012 (MUCET 2012) | 2013年 / 53卷
关键词
Modified cellulose; poly (vinyl alcohol); electrospinning; nanofibers scaffolds; bone tissue engineering; SCAFFOLD; ALIGNMENT; CELLS; SILK;
D O I
10.1016/j.proeng.2013.02.088
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
In bone tissue engineering a variety of polymers were used to develop a suitable artificial bioactive scaffold for bone tissue regeneration. In this present study, we were using modified cellulose. Randomly oriented nanofibrous scaffolds of MC and poly (vinyl alcohol) (PVA) were synthesized by electrospinning technique. The blend solutions of MC/PVA with different weight ratio of MC to PVA were prepared using water as solvent to fabricate nanofibers. The morphology, diameter of electrospun nanofibers was studied using SEM. The crystalline and thermal properties of nanofibers were investigated by DSC and chemical characterization by FTIR analysis. These results showed that MC/PVA nanofibrous scaffold provides a beneficial frame for bone tissue engineering. (C) 2013 The Authors. Published by Elsevier Ltd
引用
收藏
页码:683 / 688
页数:6
相关论文
共 23 条
[1]   Tailoring tissue engineering scaffolds using electrostatic processing techniques: A study of poly(glycolic acid) electrospinning [J].
Boland, ED ;
Wnek, GE ;
Simpson, DG ;
Pawlowski, KJ ;
Bowlin, GL .
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY, 2001, 38 (12) :1231-1243
[2]   A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue [J].
Causa, Filippo ;
Netti, Paolo A. ;
Ambrosio, Luigi .
BIOMATERIALS, 2007, 28 (34) :5093-5099
[3]   Preparation and characterization of a nanoscale poly(vinyl alcohol) fiber aggregate produced by an electrospinning method [J].
Ding, B ;
Kim, HY ;
Lee, SC ;
Shao, CL ;
Lee, DR ;
Park, SJ ;
Kwag, GB ;
Choi, KJ .
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2002, 40 (13) :1261-1268
[4]   Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects [J].
Hoemann, C. D. ;
Sun, J. ;
McKee, M. D. ;
Chevrier, A. ;
Rossomacha, E. ;
Rivard, G. -E. ;
Hurtig, M. ;
Buschmann, M. D. .
OSTEOARTHRITIS AND CARTILAGE, 2007, 15 (01) :78-89
[5]   Scaffolds in tissue engineering bone and cartilage [J].
Hutmacher, DW .
BIOMATERIALS, 2000, 21 (24) :2529-2543
[6]   Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast [J].
Lee, CH ;
Shin, HJ ;
Cho, IH ;
Kang, YM ;
Kim, IA ;
Park, KD ;
Shin, JW .
BIOMATERIALS, 2005, 26 (11) :1261-1270
[7]   Electrospun nanofibrous structure: A novel scaffold for tissue engineering [J].
Li, WJ ;
Laurencin, CT ;
Caterson, EJ ;
Tuan, RS ;
Ko, FK .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 60 (04) :613-621
[8]   A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells [J].
Li, WJ ;
Tuli, R ;
Okafor, C ;
Derfoul, A ;
Danielson, KG ;
Hall, DJ ;
Tuan, RS .
BIOMATERIALS, 2005, 26 (06) :599-609
[9]   IMMOBILIZATION OF POLY(ETHYLENE GLYCOL) ONTO A POLY(VINYL ALCOHOL) HYDROGEL .2. EVALUATION OF THROMBOGENICITY [J].
LLANOS, GR ;
SEFTON, MV .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1993, 27 (11) :1383-1391
[10]   Electrospinning of collagen nanofibers [J].
Matthews, JA ;
Wnek, GE ;
Simpson, DG ;
Bowlin, GL .
BIOMACROMOLECULES, 2002, 3 (02) :232-238