A New Sensitive Method for Quantitative Determination of Cisplatin in Biological Samples by Kinetic Spectrophotometry

被引：3

作者：

Tafazoli, Hamideh ^{[1
]}

Safaei, Mohadeseh ^{[1
]}

Shishehbore, M. Reza ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Yazd Branch, Yazd, Iran

来源：

ANALYTICAL SCIENCES | 2020年 / 36卷 / 10期

关键词：

Kinetic spectrophotometry; cisplatin; biological sample; cancer patient; METABOLITE; NANOPARTICLES; PARAMETERS; STRATEGY; THERAPY; DRUGS; ACID;

D O I：

10.2116/analsci.20P118

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This study describes a kinetic spectrophotometric method for accurate, sensitive and rapid determination of cisplatin in biofluids. The developed method is based on the inhibitory effect of cisplatin on the oxidization of Janus Green by bromate in acidic media. The change in absorbance as the criteria of the oxidation reaction was followed spectrophotometrically. To obtain the highest rate of sensitivity, efficient reaction parameters were optimized. Under optimum experimental conditions, a calibration graph was obtained linearly over the range 10.0 - 5750.0 mu g L-1 and the limit of detection (3s(b)/m) was 4.2 mu g L-1 of cisplatin. The interfering effect of diverse species was investigated. The developed method was used for the quantification of cisplatin in bio fluids of patients treated with cisplatin, spiked bio fluids and pharmaceutical samples and yielded satisfactory results.

引用

页码：1217 / 1222

页数：6

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