Preparation and purification of zinc sulfinate reagents for drug discovery

被引：57

作者：

O'Hara, Fionn ^{[1
]}

Baxter, Ryan D. ^{[1
]}

O'Brien, Alexander G. ^{[1
]}

Collins, Michael R. ^{[2
]}

Dixon, Janice A. ^{[1
]}

Fujiwara, Yuta ^{[1
]}

Ishihara, Yoshihiro ^{[1
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Pfizer Inc, La Jolla Labs, Dept Chem, San Diego, CA USA

来源：

NATURE PROTOCOLS | 2013年 / 8卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TRANSITION-METALS; ARYL; DIFLUOROMETHYLATION; INNATE; COPPER; TRIFLUOROMETHYLATION; FUNCTIONALIZATION; HETEROCYCLES; COMPLEXES; CHLORIDES;

D O I：

10.1038/nprot.2013.059

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The present protocol details the synthesis of zinc bis(alkanesulfinate)s that can be used as general reagents for the formation of radical species. The zinc sulfinates described herein are generated from the corresponding sulfonyl chlorides by treatment with zinc dust. The products may be used crude, or a simple purification procedure may be performed to minimize incorporation of water and zinc chloride. Although the synthesis of the zinc sulfinate salts can generally be completed within 3 h, workup can take up to 24 h and purification can take up to 3 h. Following the steps in this protocol would enable the user to generate a small toolkit of zinc sulfinate reagents over the course of 1 week.

引用

收藏

页码：1042 / 1047

页数：6

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