The role of cytokines in polycystic ovarian syndrome

被引：75

作者：

Ebejer, Krystle ^{[1
]}

Calleja-Agius, Jean ^{[1
,2
]}

机构：

[1] Univ Malta, Fac Med & Surg, Dept Anat, Msida, Malta

[2] Mater Dei Hosp, Dept Obstet & Gynaecol, Msida, Malta

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 2013年 / 29卷 / 06期

关键词：

Cytokines; obesity; polycystic ovary syndrome; GRADE CHRONIC INFLAMMATION; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OBESE WOMEN; PERIPHERAL-BLOOD; DISEASE; CELLS; SERUM; ROSIGLITAZONE;

D O I：

10.3109/09513590.2012.760195

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Inflammation has been implicated in the metabolic disturbances and menstrual irregularities, which characterize this condition. Various inflammatory proteins have been investigated in women with PCOS including C-reactive protein, interleukin-6, interleukin-18 and tumor necrosis factor-alpha. The data is suggestive of the presence of a chronic low-grade inflammatory state, especially in case of obesity, insulin resistance and hyperandrogenism. Targeting this inflammatory process by means of anti-inflammatory agents might be a therapeutic alternative to the current treatment.

引用

页码：536 / 540

页数：5

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