Direct conversion of bromohydrins to ketones by a free radical elimination of hydrogen bromide

被引：32

作者：

Dolenc, D ^{[1
]}

Harej, M ^{[1
]}

机构：

[1] Univ Ljubljana, Fach Chem & Chem Technol, SI-1000 Ljubljana, Slovenia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 01期

关键词：

D O I：

10.1021/jo016113y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Secondary beta-bromo alcohols can be transformed directly to ketones in very good yields by a free radical process. Tertiary beta-bromo alcohols do not react while the primary ones are transformed to aldehydes in lower yields. The reaction involves an abstraction of a hydrogen atom a to an OH group, followed by elimination of the bromine atom and subsequent tautomerization of an cool to a ketone.

引用

页码：312 / 313

页数：2

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