Trigeminal star-like platinum complexes induce cancer cell senescence through quadruplex-mediated telomere dysfunction

被引：19
作者：
Zheng, Xiao-Hui [1 ,2 ]
Mu, Ge [1 ]
Zhong, Yi-Fang [1 ]
Zhang, Tian-Peng [2 ]
Cao, Qian [1 ]
Ji, Liang-Nian [1 ]
Zhao, Yong [2 ]
Mao, Zong-Wan [1 ]
机构：
[1] Sun Yat Sen Univ, MOE Key Lab Bioinorgan & Synthet Chem, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 98期
基金：
美国国家科学基金会;
关键词：
DNA; STABILIZATION; DISSOCIATION; SHELTERIN; BINDING; TARGET;
D O I：
10.1039/c6cc08254h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two trigeminal star-like platinum complexes were synthesized to induce the formation of human telomere G-quadruplex (hTel G4) with extremely high selectivity and affinity. The induced hTel G4 activates strong telomeric DNA damage response (TDDR), resulting in telomere dysfunction and cell senescence.
引用
收藏
页码：14101 / 14104
页数：4
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