Risk factors and the natural history of accelerated knee osteoarthritis: a narrative review

被引:110
作者
Driban, Jeffrey B. [1 ]
Harkey, Matthew S. [1 ,2 ]
Barbe, Mary F. [3 ]
Ward, Robert J. [4 ]
MacKay, James W. [5 ,6 ]
Davis, Julie E. [7 ]
Lu, Bing [8 ,9 ]
Price, Lori Lyn [10 ,11 ]
Eaton, Charles B. [12 ]
Lo, Grace H. [13 ,14 ]
McAlindon, Timothy E. [1 ]
机构
[1] Tufts Med Ctr, Div Rheumatol Allergy & Immunol, 800 Washington St,Box 406, Boston, MA 02111 USA
[2] Univ Massachusetts, Med Sch, Dept Quantitat Hlth Sci, Worcester, MA USA
[3] Temple Univ, Dept Anat & Cell Biol, Sch Med, 3500 North Broad St, Philadelphia, PA 19140 USA
[4] Tufts Med Ctr, Dept Radiol, 800 Washington St, Boston, MA 02111 USA
[5] Univ Cambridge, Sch Clin Med, Dept Radiol, Box 218,Level 5, Cambridge CB2 0QQ, England
[6] Univ East Anglia, Norwich Med Sch, Dept Radiol, Res Pk, Norwich NR4 7U1, Norfolk, England
[7] George Washington Univ, Milken Inst Publ Hlth, 950 New Hampshire Ave NW, Washington, DC 20052 USA
[8] Brigham & Womens Hosp, 75 Francis St PBB-B3, Boston, MA 02115 USA
[9] Harvard Med Sch, 75 Francis St PBB-B3, Boston, MA 02115 USA
[10] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, 800 Washington St,Box 63, Boston, MA 02111 USA
[11] Tufts Univ, Tufts Clin & Translat Sci Inst, 800 Washington St,Box 63, Boston, MA 02111 USA
[12] Brown Univ, Ctr Primary Care & Prevent, Alpert Med Sch, 111 Brewster St, Pawtucket, RI 02860 USA
[13] Houston Hlth Serv Res & Dev HSR&D Ctr Excellence, Med Care Line & Res Care Line, Houston, TX USA
[14] Baylor Coll Med, Sect Immunol Allergy & Rheumatol, 1 Baylor Plaza,BCM 285, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
Knee; Osteoarthritis; Phenotype; Risk factors; Natural history; Magnetic resonance imaging; Radiography; Meniscus; ON-STUDY SAFETY; ADVERSE EVENTS; JOINT EFFUSION; IMAGING ATLAS; ANTI-NGF; SURGICAL DESTABILIZATION; STRUCTURAL-CHANGES; CARTILAGE DAMAGE; ROOT TEARS; PAIN;
D O I
10.1186/s12891-020-03367-2
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
BackgroundOsteoarthritis is generally a slowly progressive disorder. However, at least 1 in 7 people with incident knee osteoarthritis develop an abrupt progression to advanced-stage radiographic disease, many within 12months. We summarize what is known - primarily based on findings from the Osteoarthritis Initiative - about the risk factors and natural history of accelerated knee osteoarthritis (AKOA) - defined as a transition from no radiographic knee osteoarthritis to advanced-stage disease <4years - and put these findings in context with typical osteoarthritis (slowly progressing disease), aging, prior case reports/series, and relevant animal models.SummaryRisk factors in the 2 to 4years before radiographic manifestation of AKOA (onset) include older age, higher body mass index, altered joint alignment, contralateral osteoarthritis, greater pre-radiographic disease burden (structural, symptoms, and function), or low fasting glucose. One to 2years before AKOA onset people often exhibit rapid articular cartilage loss, larger bone marrow lesions and effusion-synovitis, more meniscal pathology, slower chair-stand or walking pace, and increased global impact of arthritis than adults with typical knee osteoarthritis. Increased joint symptoms predispose a person to new joint trauma, which for someone who develops AKOA is often characterized by a destabilizing meniscal tear (e.g., radial or root tear). One in 7 people with AKOA onset subsequently receive a knee replacement during a 9-year period. The median time from any increase in radiographic severity to knee replacement is only 2.3years. Despite some similarities, AKOA is different than other rapidly progressive arthropathies and collapsing these phenomena together or extracting results from one type of osteoarthritis to another should be avoided until further research comparing these types of osteoarthritis is conducted. Animal models that induce meniscal damage in the presence of other risk factors or create an incongruent distribution of loading on joints create an accelerated form of osteoarthritis compared to other models and may offer insights into AKOA.ConclusionAccelerated knee osteoarthritis is unique from typical knee osteoarthritis. The incidence of AKOA in the Osteoarthritis Initiative and Chingford Study is substantial. AKOA needs to be taken into account and studied in epidemiologic studies and clinical trials.
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页数:11
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