Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations

被引：5
作者：
van der Hoek, W. [1 ]
Wielders, C. C. H. [1 ,2 ]
Schimmer, B. [1 ]
Wegdam-Blans, M. C. A. [3 ]
Meekelenkamp, J. [2 ]
Zaaijer, H. L. [4 ,5 ]
Schneeberger, P. M. [1 ,2 ]
机构：
[1] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3720 BA Bilthoven, Netherlands
[2] Jeroen Bosch Hosp, Dept Med Microbiol & Infect Control, sHertogenbosch, Netherlands
[3] Lab Pathol & Med Microbiol PAMM, Veldhoven, Netherlands
[4] Sanquin Blood Supply Fdn, Dept Blood Borne Infect, Amsterdam, Netherlands
[5] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2012年 / 31卷 / 11期
关键词：
ACUTE Q-FEVER; FOLLOW-UP; NETHERLANDS; INFECTION;
D O I：
10.1007/s10096-012-1686-7
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (a parts per thousand yen1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes.
引用
收藏
页码：3207 / 3209
页数：3
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