Hepatic expression of sodium-glucose cotransporter 2 (SGLT2) in patients with chronic liver disease

被引：17

作者：

Nakano, Dan ^{[1
]}

Akiba, Jun ^{[2
]}

Tsutsumi, Tsubasa ^{[1
]}

Kawaguchi, Machiko ^{[1
]}

Yoshida, Takafumi ^{[1
]}

Koga, Hironori ^{[1
,3
]}

Kawaguchi, Takumi ^{[1
,3
]}

机构：

[1] Kurume Univ, Dept Med, Div Gastroenterol, Sch Med, 67 Asahi Machi Kurume, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ Hosp, Dept Pathol, Kurume, Fukuoka, Japan

[3] Kurume Univ, Res Ctr Innovat Canc Therapy, Liver Canc Div, Kurume, Fukuoka, Japan

来源：

MEDICAL MOLECULAR MORPHOLOGY | 2022年 / 55卷 / 04期

基金：

日本学术振兴会;

关键词：

Glucose transporter; SGLT2; Liver; Human tissue; Graphical model; CANAGLIFLOZIN; INHIBITOR; TRANSPORTERS; METABOLISM;

D O I：

10.1007/s00795-022-00334-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sodium-glucose cotransporter 2 (SGLT2) occurs in the proximal renal tubule cells. We investigate the hepatic expression of SGLT2 and its related factors in patients with chronic liver disease. This is a retrospective human study. The liver tissues were biopsied from patients with chronic liver disease (n = 30). The expression levels of SGLT2 were evaluated by immunostaining. Furthermore, the undirected graphical model was used to identify factors associated with hepatic expression levels of SGLT2. The SGLT2 expression was observed in not only the kidney, but also the liver in immunostaining (SGLT2 intensity: kidney 165.8 +/- 15.6, liver 114.4 +/- 49.0 arbitrary units, P < 0.01) and immunoblotting. There was no significant difference in hepatic expression of SGLT2 in the stratified analysis according to age, sex, BMI, and the severity of the liver disease. In the undirected graphical model, SGLT2 directly interacted with various factors such as sex, fatty change, neutrophil-to-lymphocyte ratio, triglyceride, hemoglobin A1c, creatinine, and albumin (partial correlation coefficient 0.4-0.6 for sex and 0.2-0.4 for others). The expression of SGLT2 was observed in the hepatocytes of patients with chronic liver disease. The undirected graphical model demonstrated the complex interaction of hepatic expression levels of SGLT2 with gender, inflammation, renal function, and lipid/glucose/protein metabolisms.

引用

页码：304 / 315

页数：12