Chemoenzymatic Synthesis and Anti-Inflammatory Activity of Fatty Acid Amides Prepared from Bertholletia excelsa (Brazil Nut) Triglycerides

被引：8

作者：

Barata, Pedro H. S. ^{[1
]}

Sarquis, Icaro R. ^{[1
]}

Carvalho, Helison O. ^{[2
]}

Barros, Albenise S. ^{[2
]}

Rodrigues, Alex B. ^{[1
]}

Galue-Parra, Adan J. ^{[3
]}

Silva, Edilene O. ^{[3
,4
]}

Carvalho, Jos Carlos T. ^{[2
]}

Ferreira, Irlon M. ^{[1
,3
]}

机构：

[1] Univ Fed Amapa, Dept Ciencias Exatas & Tecnol, BR-68902280 Macapa, AP, Brazil

[2] Univ Fed Amapa, Dept Ciencias Biol & Saude, BR-68902280 Macapa, AP, Brazil

[3] Univ Fed Para, Inst Ciencias Biol, BR-66075110 Belem, Para, Brazil

[4] Inst Nacl Ciencia & Tecnol Biol Estrutural & Bioi, BR-21941902 Rio De Janeiro, RJ, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2020年 / 31卷 / 08期

关键词：

direct aminolysis; biocatalysis; oleoylethanolamine; palmitoethanolamide; alkylamides; LARVICIDAL ACTIVITY; AMINOLYSIS; LIPASE; ENDOCANNABINOIDS; SOLVENT; OIL; FLUORESCENS; SURFACTANTS; DERIVATIVES; INHIBITORS;

D O I：

10.21577/0103-5053.20200041

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study reports the synthesis of fatty acid amides (FAA), analogous to anandamide, prepared from Brazil nut oil (BNO), using Amano lipase from Pseudomonas fluorescens as a catalyst of direct aminolysis, with a good yield (95-68%). The anti-inflammatory effects of BNO and FAA were evaluated by the carrageenan-induced paw edema method. Analysis of the formation of edema showed that these FAA, at all dose used, significantly reduced the development of edema.

引用

页码：1557 / 1565

页数：9

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