Nasopharyngeal Nonkeratinizing (Undifferentiated) Monstrous Cell Carcinoma A Case Report

被引：0
作者：
Avci, Arzu [2 ]
Gunhan, Omer [1 ]
Karslioglu, Yildirim [1 ]
Celasun, Bulent [3 ]
机构：
[1] Gulhane Mil Med Acad, Dept Pathol, TR-06018 Ankara, Turkey
[2] Ataturk Res & Educ Hosp, Izmir, Turkey
[3] Goren Pathol Lab, Ankara, Turkey
来源：
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY | 2011年 / 33卷 / 05期
关键词：
Epstein-Barr virus; monstrous cell; nasopharyngeal carcinoma; nonkeratinizing carcinoma; tumor giant cell; FLOW-CYTOMETRIC ANALYSIS;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
BACKGROUND: The histologic type of nasopharyngeal carcinoma can be an important factor in the prognosis. The effects, if any, of the degree of cellular pleomorphism is uncertain. CASE: In this report, we present a case of nonkeratinizing, undifferentiated nasopharyngeal carcinoma with monstrous tumor giant cells. An extremely high level of aneuploidy and dense cytoplasmic accumulation of Epstein-Barr virus capsid antigen were found in tumor cells. The patient was treated with concomitant chemoradiotherapy. CONCLUSION: Nine years of follow-up with no recurrences suggests that this extreme morphologic variation may impart no adverse prognostic effect. (Anal Quant Cytol Histol 2011;33:297-302)
引用
收藏
页码：297 / 302
页数：6
相关论文
共 25 条
[1]   Nasopharyngeal carcinoma: Current management, future directions and dental implications [J].
Agulnik, Mark ;
Epstein, Joel B. .
ORAL ONCOLOGY, 2008, 44 (07) :617-627
[2]  
Barnes L., 2005, WHO CLASSIFICATION T, P81
[3]   Nasopharyngeal carcinoma [J].
Brennan, Bernadette .
ORPHANET JOURNAL OF RARE DISEASES, 2006, 1 (1)
[4]  
Carpenter DH, 2011, MODERN PATHOL, DOI [10.1038/modpathol.2011.87, DOI 10.1038/M0DPATH0L.2011.87]
[5]   Nasopharyngeal carcinoma [J].
Chan, ATC ;
Teo, PML ;
Johnson, PJ .
ANNALS OF ONCOLOGY, 2002, 13 (07) :1007-1015
[6]   Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells [J].
Chang, THT ;
Ray, FA ;
Thompson, DA ;
Schlegel, R .
ONCOGENE, 1997, 14 (20) :2383-2393
[7]  
Chen MH, 2004, ANAL QUANT CYTOL, V26, P255
[8]   Nasopharyngeal carcinoma - Review of the molecular mechanisms of tumorigenesis [J].
Chou, Josephine ;
Lin, Yu-Ching ;
Kim, Jae ;
You, Liang ;
Xu, Zhidong ;
He, Biao ;
Jablons, David M. .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2008, 30 (07) :946-963
[9]  
COSTELLO F, 1990, CANCER-AM CANCER SOC, V66, P1789, DOI 10.1002/1097-0142(19901015)66:8<1789::AID-CNCR2820660825>3.0.CO
[10]  
2-F
123