An Insight into the Sialotranscriptome of Triatoma matogrossensis, a Kissing Bug Associated with Fogo Selvagem in South America

被引：32

作者：

Assumpcao, Teresa C. F. ^{[1
]}

Eaton, Donald P. ^{[2
]}

Pham, Van M. ^{[1
]}

Francischetti, Ivo M. B. ^{[1
]}

Aoki, Valeria ^{[3
]}

Hans-Filho, Gunter ^{[4
]}

Rivitti, Evandro A. ^{[3
]}

Valenzuela, Jesus G. ^{[1
]}

Diaz, Luis A. ^{[5
]}

Ribeiro, Jose M. C. ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20892 USA

[2] Wildlife Conservat Soc Brazo, Campo Grande, MS, Brazil

[3] Univ Sao Paulo, Dept Dermatol, BR-05508 Sao Paulo, Brazil

[4] Univ Fed Mato Grosso do Sul, Dept Dermatol, Campo Grande, Brazil

[5] Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27514 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2012年 / 86卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MULTIPLE SEQUENCE ALIGNMENT; ENVIRONMENTAL RISK-FACTORS; LIPOCALIN PROTEIN FAMILY; LOW-LEVEL INFESTATION; PEMPHIGUS FOLIACEUS; PLATELET-AGGREGATION; BLOODSUCKING BUG; SALIVARY-GLAND; OLIVEIRAI COMPLEX; AMERINDIAN RESERVATION;

D O I：

10.4269/ajtmh.2012.11-0690

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, a vector of Chagas' disease that feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure to T. matogrossensis was also found to be a risk factor associated with the endemic form of the autoimmune skin disease pemphigus foliaceus, which is described in the same regions where Chagas' disease is observed in Brazil. To obtain a further insight into the salivary biochemical and pharmacologic diversity of this kissing bug and to identify possible allergens that might be associated with this autoimmune disease, a cDNA library from its SGs was randomly sequenced. We present the analysis of a set of 2,230 (SG) cDNA sequences, 1,182 of which coded for proteins of a putative secretory nature.

引用

页码：1005 / 1014

页数：10

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