Prognostic factors and clinical outcomes in synovial sarcoma of the extremities

被引:10
作者
Wisanuyotin, Taweechok [1 ]
Radapat, Krisana [1 ]
Sirichativapee, Winai [1 ]
Paholpak, Permsak [1 ]
Kosuwon, Weerachai [1 ]
Sumnanoont, Chat [1 ]
Jeeravipoolvarn, Polasak [1 ]
机构
[1] Khon Kaen Univ, Fac Med, Dept Orthopaed, Khon Kaen 40002, Thailand
关键词
clinical outcomes; extremities; prognostic factors; survival; synovial sarcoma; SSX-FUSION-TYPE; MULTIVARIATE-ANALYSIS; RETROSPECTIVE ANALYSIS; TUMOR SIZE; CHEMOTHERAPY; MULTICENTER; ADOLESCENCE; CHILDHOOD; CHILDREN; SURVIVAL;
D O I
10.1111/j.1743-7563.2012.01563.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims To evaluate the clinical outcomes and identify which prognostic factors influence the clinical outcomes of synovial sarcoma patients at a tertiary university hospital in Thailand. Methods Patients with synovial sarcoma of the extremities between 1997 and 2007 were reviewed from the database of the Musculoskeletal Oncology Unit, Srinagarind Hospital, Khon Kaen University, Khon Kaen, Thailand. Results Of 41 patients, 23 males (56%) and 18 females (44%) with a median age of 39 (range, 178years), 18 (44%) had metastasis at the first diagnosis and 23 (56%) had only a localized tumor. The 5-year overall survival of all the patients was 36%; 64% in patients with localized disease and 0% in patients with metastasis at first diagnosis. In all 23 patients (56%) died of the disease at a median duration of 11months (range 347months). All patients with metastases died at a median 9months (range 141months). Metastasis at first diagnosis influenced overall survival for patients with synovial sarcoma (P<0.001). According to a univariate analysis, the significant adverse factors were biphasic histological subtype and an inadequate surgical margin of the definitive surgery (P<0.05). Conclusion Synovial sarcoma is still a disease with a poor prognosis. Distant metastasis at initial diagnosis is a significant adverse prognostic factor for overall survival. A biphasic histological subtype and an inadequate surgical margin are significant adverse prognostic factors in localized synovial sarcoma.
引用
收藏
页码:80 / 85
页数:6
相关论文
共 29 条
[1]  
Bergh P, 1999, CANCER-AM CANCER SOC, V85, P2596, DOI 10.1002/(SICI)1097-0142(19990615)85:12<2596::AID-CNCR16>3.0.CO
[2]  
2-K
[3]   Grossly-resected synovial sarcoma treated by the German and Italian pediatric soft tissue sarcoma cooperative groups: Discussion on the role of adjuvant therapies [J].
Brecht, IB ;
Ferrari, A ;
Int-Veen, C ;
Schuck, A ;
Mattke, AC ;
Casanova, M ;
Bisogno, G ;
Carli, M ;
Koscielniak, E ;
Treuner, J .
PEDIATRIC BLOOD & CANCER, 2006, 46 (01) :11-17
[4]   Synovial Sarcoma in Childhood and Adolescence: A Retrospective Series of 77 Patients Registered by the Children's Cancer and Leukaemia Group Between 1991 and 2006 [J].
Brennan, Bernadette ;
Stevens, Michael ;
Kelsey, Anna ;
Stiller, Charles A. .
PEDIATRIC BLOOD & CANCER, 2010, 55 (01) :85-90
[5]   A Synovial Sarcoma-Specific Preoperative Nomogram Supports a Survival Benefit to Ifosfamide-Based Chemotherapy and Improves Risk Stratification for Patients [J].
Canter, Robert J. ;
Qin, Li-Xuan ;
Maki, Robert G. ;
Brennan, Murray F. ;
Ladanyi, Marc ;
Singer, Samuel .
CLINICAL CANCER RESEARCH, 2008, 14 (24) :8191-8197
[6]   Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma [J].
Eilber, Fritz C. ;
Brennan, Murray F. ;
Eilber, Frederick R. ;
Eckardt, Jeffery J. ;
Grobmyer, Stephen R. ;
Riedel, Elyn ;
Forscher, Charles ;
Maki, Robert G. ;
Singer, Samuel .
ANNALS OF SURGERY, 2007, 246 (01) :105-113
[7]   Synovial sarcoma: A retrospective analysis of 271 patients of all ages treated at a single institution [J].
Ferrari, A ;
Gronchi, A ;
Casanova, M ;
Meazza, C ;
Gandola, L ;
Collini, P ;
Lozza, L ;
Bertulli, R ;
Olmi, P ;
Casali, PG .
CANCER, 2004, 101 (03) :627-634
[8]  
Ferrari A, 1999, MED PEDIATR ONCOL, V32, P32, DOI 10.1002/(SICI)1096-911X(199901)32:1<32::AID-MPO7>3.0.CO
[9]  
2-1
[10]   Synovial sarcoma of children and adolescents: The prognostic role of axial sites [J].
Ferrari, Andrea ;
Bisogno, Gianni ;
Alaggio, Rita ;
Cecchetto, Giovanni ;
Collini, Paola ;
Rosolen, Angelo ;
Meazza, Cristina ;
Indolfi, Paolo ;
Garaventa, Alberto ;
De Sio, Luigi ;
D'Angelo, Paolo ;
Tamaro, Paolo ;
Casanova, Michela ;
Carli, Modesto .
EUROPEAN JOURNAL OF CANCER, 2008, 44 (09) :1202-1209