Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons

被引：80

作者：

Gilca, R

De Serres, G

Tremblay, M

Vachon, ML

Leblanc, E

Bergeron, MG

Déry, P

Boivin, G

机构：

[1] Univ Laval, Quebec City, PQ, Canada

[2] Quebec Natl Inst Publ Hlth, Quebec City, PQ, Canada

[3] Res Ctr Infect Dis, Quebec City, PQ, Canada

[4] Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2006年 / 193卷 / 01期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1086/498526

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children <= 3 years old over 2 winters. Clinical data were compared between 106 children infected with group A hRSV (96 GA2 genotypes) and 94 children infected with hRSV group B (62 GB3 genotypes). A severity index was defined by assigning 1 point each for the use of > 30% supplemental oxygen, admission to an intensive-care unit, and duration of hospital stay of 15 days. Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains.

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收藏

页码：54 / 58

页数：5

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