An Outbreak of Ebola Virus Disease in the Lassa Fever Zone

被引：26

作者：

Goba, Augustine ^{[1
]}

Khan, S. Humarr ^{[1
]}

Fonnie, Mbalu ^{[1
]}

Fullah, Mohamed ^{[1
]}

Moigboi, Alex ^{[1
]}

Kovoma, Alice ^{[1
]}

Sinnah, Vandi ^{[1
]}

Yoko, Nancy ^{[1
]}

Rogers, Hawa ^{[1
]}

Safai, Siddiki ^{[1
]}

Momoh, Mambu ^{[1
]}

Koroma, Veronica ^{[1
]}

Kamara, Fatima K. ^{[1
]}

Konowu, Edwin ^{[1
]}

Yillah, Mohamed ^{[1
]}

French, Issa ^{[1
]}

Mustapha, Ibraham ^{[1
]}

Kanneh, Franklyn ^{[1
]}

Foday, Momoh ^{[1
]}

McCarthy, Helena ^{[1
]}

Kallon, Tiangay ^{[1
]}

Kallon, Mustupha ^{[1
]}

Naiebu, Jenneh ^{[1
]}

Sellu, Josephine ^{[1
]}

Jalloh, Abdul A. ^{[1
]}

Gbakie, Michael ^{[1
]}

Kanneh, Lansana ^{[1
]}

Massaly, James L. B. ^{[2
]}

Kargbo, David ^{[2
]}

Kargbo, Brima ^{[2
]}

Vandi, Mohamed ^{[2
]}

Gbetuwa, Momoh ^{[2
]}

Gevao, Sahr M. ^{[3
]}

Sandi, John D. ^{[1
]}

Jalloh, Simbirie C. ^{[1
]}

Grant, Donald S. ^{[1
,2
]}

Blyden, Sylvia O. ^{[4
]}

Crozier, Ian ^{[5
,6
]}

Schieffelin, John S. ^{[7
,8
]}

McLellan, Susan L. ^{[7
,8
,11
]}

Jacob, Shevin T. ^{[17
]}

Boisen, Matt L. ^{[18
,20
]}

Hartnett, Jessica N. ^{[9
]}

Cross, Robert W. ^{[19
]}

Branco, Luis M. ^{[20
]}

Andersen, Kristian G. ^{[21
]}

Yozwiak, Nathan L. ^{[25
]}

Gire, Stephen K. ^{[24
]}

Tariyal, Ridhi ^{[24
]}

Park, Daniel J. ^{[25
]}

机构：

[1] Kenema Govt Hosp, Viral Hemorrhag Fever Program, Freetown, Sierra Leone

[2] Minist Hlth & Sanitat, Freetown, Sierra Leone

[3] Univ Sierra Leone, Freetown, Sierra Leone

[4] Minist Social Welf Gender & Childrens Affairs, Freetown, Sierra Leone

[5] WHO, Sierra Leone Ebola Response Team, Freetown, Sierra Leone

[6] Mulago Hosp Complex, Infect Dis Inst, Kampala, Uganda

[7] Tulane Univ, Dept Pediat, Sect Infect Dis, New Orleans, LA 70118 USA

[8] Tulane Univ, Sch Med, Dept Internal Med, Sect Infect Dis, 1430 Tulane Ave, New Orleans, LA 70112 USA

[9] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA

[10] Tulane Univ, Dept Biochem, New Orleans, LA 70118 USA

[11] Tulane Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA USA

[12] Tulane Sch Publ Hlth & Trop Med, Dept Biostat & Bioinformat, New Orleans, LA USA

[13] LSU Hlth, Dept Microbiol Immunol & Parasitol, New Orleans, LA USA

[14] South Coast Solar, New Orleans, LA USA

[15] Autoimmune Technol, New Orleans, LA USA

[16] Mockingbird Nat Res Grp, Pearl River, LA USA

[17] Univ Washington, Div Allergy & Infect Dis, Seattle, WA 98195 USA

[18] Corgenix, Broomfield, CO USA

[19] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[20] Zalgen Labs, Germantown, MD USA

[21] Scripps Res Inst, Scripps Translat Sci Inst, La Jolla, CA 92037 USA

[22] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[23] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[24] NextGen Jane, San Francisco, CA USA

[25] Broad Inst MIT & Harvard, Cambridge, MA USA

[26] Harvard Univ, Dept Organism & Evolutionary Biol, Ctr Syst Biol, Cambridge, MA 02138 USA

[27] Mt Sinai Sch Med, New York, NY USA

[28] Vybion, New York, NY USA

[29] Naval Engn Facil Command, Naples, Italy

[30] Redeemers Univ, Ede, Nigeria

[31] Irrua Specialist Teaching Hosp, Irrua, Nigeria

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷

基金：

美国国家卫生研究院;

关键词：

West African Ebola outbreak 2013-16; Ebola virus; Lassa virus; research capacity building; viral hemorrhagic fever diagnostics; epidemiology; genomic sequencing; REVERSE TRANSCRIPTION-PCR; OUTCOME CASE-REPORT; SIERRA-LEONE; HEMORRHAGIC-FEVER; VIRAL LOAD; DIAGNOSTICS; EVOLUTION; PATIENT; TRANSMISSION; FILOVIRUSES;

D O I：

10.1093/infdis/jiw239

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Kenema Government Hospital (KGH) has developed an advanced clinical and laboratory research capacity to manage the threat of Lassa fever, a viral hemorrhagic fever (VHF). The 2013- 2016 Ebola virus (EBOV) disease (EVD) outbreak is the first to have occurred in an area close to a facility with established clinical and laboratory capacity for study of VHFs. Methods.aEuro integral Because of its proximity to the epicenter of the EVD outbreak, which began in Guinea in March 2014, the KGH Lassa fever Team mobilized to establish EBOV surveillance and diagnostic capabilities. Results.aEuro integral Augustine Goba, director of the KGH Lassa laboratory, diagnosed the first documented case of EVD in Sierra Leone, on 25 May 2014. Thereafter, KGH received and cared for numbers of patients with EVD that quickly overwhelmed the capacity for safe management. Numerous healthcare workers contracted and lost their lives to EVD. The vast majority of subsequent EVD cases in West Africa can be traced back to a single transmission chain that includes this first diagnosed case. Conclusions.aEuro integral Responding to the challenges of confronting 2 hemorrhagic fever viruses will require continued investments in the development of countermeasures (vaccines, therapeutic agents, and diagnostic assays), infrastructure, and human resources.

引用

页码：S110 / S121

页数：12

共 52 条

[1] Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
Andersen, Kristian G.
Shapiro, B. Jesse
Matranga, Christian B.
Sealfon, Rachel
Lin, Aaron E.
Moses, Lina M.
Folarin, Onikepe A.
Goba, Augustine
Odia, Ikponmwonsa
Ehiane, Philomena E.
Momoh, Mambu
England, Eleina M.
Winnicki, Sarah
Branco, Luis M.
Gire, Stephen K.
Phelan, Eric
Tariyal, Ridhi
Tewhey, Ryan
Omoniwa, Omowunmi
Fullah, Mohammed
Fonnie, Richard
Fonnie, Mbalu
Kanneh, Lansana
Jalloh, Simbirie
Gbakie, Michael
Saffa, Sidiki
Karbo, Kandeh
Gladden, Adrianne D.
Qu, James
Stremlau, Matthew
Nekoui, Mahan
Finucane, Hilary K.
Tabrizi, Shervin
Vitti, Joseph J.
Birren, Bruce
Fitzgerald, Michael
McCowan, Caryn
Ireland, Andrea
Berlin, Aaron M.
Bochicchio, James
Tazon-Vega, Barbara
Lennon, Niall J.
Ryan, Elizabeth M.
Bjornson, Zach
Milner, Danny A., Jr.
Lukens, Amanda K.
Broodie, Nisha
Rowland, Megan
Heinrich, Megan
Akdag, Marjan
[J]. CELL, 2015, 162 (04) : 738 - 750
[2] [Anonymous], 2014, NY TIMES
[3] Molecular Diagnostics for Lassa Fever at Irrua Specialist Teaching Hospital, Nigeria: Lessons Learnt from Two Years of Laboratory Operation
Asogun, Danny A.
Adomeh, Donatus I.
Ehimuan, Jacqueline
Odia, Ikponmwonsa
Hass, Meike
Gabriel, Martin
Oelschlaeger, Stephan
Becker-Ziaja, Beate
Folarin, Onikepe
Phelan, Eric
Ehiane, Philomena E.
Ifeh, Veritas E.
Uyigue, Eghosasere A.
Oladapo, Yemisi T.
Muoebonam, Ekene B.
Osunde, Osagie
Dongo, Andrew
Okokhere, Peter O.
Okogbenin, Sylvanus A.
Momoh, Mojeed
Alikah, Sylvester O.
Akhuemokhan, Odigie C.
Imomeh, Peter
Odike, Maxy A. C.
Gire, Stephen
Andersen, Kristian
Sabeti, Pardis C.
Happi, Christian T.
Akpede, George O.
Guenther, Stephan
[J]. PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (09):
[4] Emergence of Zaire Ebola Virus Disease in Guinea
Baize, Sylvain
Pannetier, Delphine
Oestereich, Lisa
Rieger, Toni
Koivogui, Lamine
Magassouba, N'Faly
Soropogui, Barre
Sow, Mamadou Saliou
Keita, Sakoba
De Clerck, Hilde
Tiffany, Amanda
Dominguez, Gemma
Loua, Mathieu
Traore, Alexis
Kolie, Moussa
Malano, Emmanuel Roland
Heleze, Emmanuel
Bocquin, Anne
Mely, Stephane
Raoul, Herve
Caro, Valerie
Cadar, Daniel
Gabriel, Martin
Pahlmann, Meike
Tappe, Dennis
Schmidt-Chanasit, Jonas
Impouma, Benido
Diallo, Abdoul Karim
Formenty, Pierre
Van Herp, Michel
Guenther, Stephan
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (15) : 1418 - 1425
[5] Lassa Fever in Guinea: I. Epidemiology of Human Disease and Clinical Observations
Bausch, Daniel G.
Demby, Austin H.
Coulibaly, Mamadi
Kanu, James
Goba, Augustine
Bah, Alpha
Conde, Nancouma
Wurtzel, Heather L.
Cavallaro, Kathleen F.
Lloyd, Ethleen
Baldet, Fatoumata Binta
Cisse, Sekou D.
Fofona, Djicondet
Savane, Ibrahim K.
Tolno, Robert Tamba
Mahy, Barry
Wagoner, Kent D.
Ksiazek, Thomas G.
Peters, C. J.
Rollin, Pierre E.
[J]. VECTOR-BORNE AND ZOONOTIC DISEASES, 2001, 1 (04) : 269 - +
[6] Aniru Conteh 1942-2004 - In memoriam
Bausch, DG
Sesay, SSS
Oshin, B
[J]. EMERGING INFECTIOUS DISEASES, 2004, 10 (10) : 1889 - 1890
[7] Blyden S, 2014, AWARENESS TIMES 0929
[8] Multiple Circulating Infections Can Mimic the Early Stages of Viral Hemorrhagic Fevers and Possible Human Exposure to Filoviruses in Sierra Leone Prior to the 2014 Outbreak
Boisen, Matthew L.
Schieffelin, John S.
Goba, Augustine
Oottamasathien, Darin
Jones, Abigail B.
Shaffer, Jeffrey G.
Hastie, Kathryn M.
Hartnett, Jessica N.
Momoh, Mambu
Fullah, Mohammed
Gabiki, Michael
Safa, Sidiki
Zandonatti, Michelle
Fusco, Marnie
Bornholdt, Zach
Abelson, Dafna
Gire, Stephen K.
Andersen, Kristian G.
Tariyal, Ridhi
Stremlau, Mathew
Cross, Robert W.
Geisbert, Joan B.
Pitts, Kelly R.
Geisbert, Thomas W.
Kulakoski, Peter
Wilson, Russell B.
Henderson, Lee
Sabeti, Pardis C.
Grant, Donald S.
Garry, Robert F.
Saphire, Erica O.
Branco, Luis M.
Khan, Sheik Humarr
[J]. VIRAL IMMUNOLOGY, 2015, 28 (01) : 19 - 31
[9] Lassa hemorrhagic fever in a late term pregnancy from northern sierra leone with a positive maternal outcome: case report
Branco, Luis M.
Boisen, Matt L.
Andersen, Kristian G.
Grove, Jessica N.
Moses, Lina M.
Muncy, Ivana J.
Henderson, Lee A.
Schieffellin, John S.
Robinson, James E.
Bangura, James J.
Grant, Donald S.
Raabe, Vanessa N.
Fonnie, Mbalu
Sabeti, Pardis C.
Garry, Robert F.
[J]. VIROLOGY JOURNAL, 2011, 8
[10] ReEBOV Antigen Rapid Test kit for point-of-care and laboratory-based testing for Ebola virus disease: a field validation study
Broadhurst, Mara Jana
Kelly, John Daniel
Miller, Ann
Semper, Amanda
Bailey, Daniel
Groppelli, Elisabetta
Simpson, Andrew
Brooks, Tim
Hula, Susan
Nyoni, Wilfred
Sankoh, Alhaji B.
Kanu, Santigi
Jalloh, Alhaji
Ton, Quy
Sarchet, Nicholas
George, Peter
Perkins, Mark D.
Wonderly, Betsy
Murray, Megan
Pollock, Nira R.
[J]. LANCET, 2015, 386 (9996) : 867 - 874

← 1 2 3 4 5 6 →