Cu(OAc)2/TFA-Promoted Formal [3+3] Cycloaddition/Oxidation of Enamines and Enones for Synthesis of Multisubstituted Aromatic Amines

被引：46

作者：

Li, Liang ^{[1
]}

Zhao, Mi-Na ^{[1
]}

Ren, Zhi-Hui ^{[1
]}

Li, Jian-Li ^{[1
]}

Guan, Zheng-Hui ^{[1
]}

机构：

[1] NW Univ Xian, Dept Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 13期

基金：

中国国家自然科学基金;

关键词：

DIPHENYLPROLINOL SILYL ETHER; AZOMETHINE IMINES; ROUTE; ARYL; MIGRATION; CYCLIZATION; ANNULATION; KETONES; CONSTRUCTION; 1,2-ARYL;

D O I：

10.1021/ol3014733

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New strategies for the oxidative cycloaddition of enones with enamines are developed. These cycloaddition reactions directly afford substituted aromatic amines, which are important in organic chemistry, in moderate to good yield. Cu(OAc)(2)/TFA is shown to be essential to achieve high reaction efficiency.

引用

页码：3506 / 3509

页数：4

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