In this paper, a double line pier on a high-speed railway in China is taken as an example. the size of each location is drawn up firstly. The design of pre-stressed steel beam for its crossbeam is carried out, and the configuration of ordinary reinforcement is carried out for concrete piers. Combined with bridge structure analysis software Midas Civil and BSAS, the frame pier is modeled and calculated. The results show that the beam and pier column section size reasonable design of pre-stressed steel beam with 17-7 Phi 5 high strength low relaxation steel strand, can meet the requirements of high speed railway carrying capacity; the main reinforcement of pier shaft with HRB400 diameter is 28mm, ring arranged around the pier, can satisfy the eccentric compression strength, stiffness and stability requirements, also meet the requirements of seismic design.