Role of Microbiota in Pathogenesis and Management of Viral Hepatitis

被引：33

作者：

Sehgal, Rashi ^{[1
]}

Bedi, Onkar ^{[1
]}

Trehanpati, Nirupma ^{[1
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Mol & Cellular Med, New Delhi, India

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2020年 / 10卷

关键词：

hepatitis; fecal microbiota transplantation; gut microbiota; lipopolysaccharides (LPS); probiotic; bacteria; GUT MICROBIOTA; THERAPEUTIC TARGET; LIVER; CIRRHOSIS; TRANSPLANTATION; INFECTION; EXPRESSION; COMMENSAL; BUTYRATE; BACTERIA;

D O I：

10.3389/fcimb.2020.00341

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis is a condition that can be self-limiting or can progress to fibrosis (scarring), cirrhosis, or liver cancer. These days, gut microbiota becomes an important part of our immune system, which is important for disease progression or recovery. Translocation of gut microbial and metabolic products causes intestinal inflammation by modulating immune cells leading to impairment of the primary barrier. But there are limited studies discussing pathogenesis and management of hepatitis with gut microbiota. In this review, we have discussed the role of gut microbiota in pathogenesis and management of various hepatitis, especially hepatitis B and C. We have discussed the role of bacterial products, LPS-TLR4 pathway, and unmethylated CpG DNA, which ultimately affects downstream NF-kB signaling in hepatitis. Finally, we have discussed the role of fecal microbiota transplantation in the management of hepatitis.

引用

页数：8

共 64 条

[51] Longitudinal Survey of Fungi in the Human Gut: ITS Profiling, Phenotyping, and Colonization [J].

Raimondi, Stefano ;

Amaretti, Alberto ;

Gozzoli, Caterina ;

Simone, Marta ;

Righini, Lucia ;

Candeliere, Francesco ;

Brun, Paola ;

Ardizzoni, Andrea ;

Colombari, Bruna ;

Paulone, Simona ;

Castagliuolo, Ignazio ;

Cavalieri, Duccio ;

Blasi, Elisabetta ;

Rossi, Maddalena ;

Peppoloni, Samuele .

FRONTIERS IN MICROBIOLOGY, 2019, 10

[52] Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma [J].

Ren, Zhigang ;

Li, Ang ;

Jiang, Jianwen ;

Zhou, Lin ;

Yu, Zujiang ;

Lu, Haifeng ;

Xie, Haiyang ;

Chen, Xiaolong ;

Shao, Li ;

Zhang, Ruiqing ;

Xu, Shaoyan ;

Zhang, Hua ;

Cui, Guangying ;

Chen, Xinhua ;

Sun, Ranran ;

Wen, Hao ;

Lerut, Jan P. ;

Kan, Quancheng ;

Li, Lanjuan ;

Zheng, Shusen .

GUT, 2019, 68 (06) :1014-1023

[53] Microbiome as a therapeutic target in alcohol-related liver disease [J].

Sarin, Shiv K. ;

Pande, Apurva ;

Schnabl, Bernd .

JOURNAL OF HEPATOLOGY, 2019, 70 (02) :260-272

[54] Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut [J].

Seki, Ekihiro ;

Schnabl, Bernd .

JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (03) :447-458

[55] Is frozen fecal microbiota transplantation as effective as fresh fecal microbiota transplantation in patients with recurrent or refractory Clostridium difficile infection: A meta-analysis? [J].

Tang, Guihua ;

Yin, Wen ;

Liu, Wenen .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2017, 88 (04) :322-329

[56] Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein [J].

Visvanathan, Kumar ;

Skinner, Narelle A. ;

Thompson, Alex J. V. ;

Riordan, Stephen M. ;

Sozzi, Vitini ;

Edwards, Roslyn ;

Rodgers, Sally ;

Kurtovic, Jelica ;

Chang, Judy ;

Lewin, Sharon ;

Desmond, Paul ;

Locarnini, Stephen .

HEPATOLOGY, 2007, 45 (01) :102-110

[57] Gut Microbial Dysbiosis Is Associated with Altered Hepatic Functions and Serum Metabolites in Chronic Hepatitis B Patients [J].

Wang, Jing ;

Wang, Yang ;

Zhang, Xu ;

Liu, Jiaqi ;

Zhang, Qianpeng ;

Zhao, Yu ;

Peng, Jinghua ;

Feng, Qin ;

Dai, Jianye ;

Sun, Shujun ;

Zhao, Yufeng ;

Zhao, Liping ;

Zhang, Yongyu ;

Hu, Yiyang ;

Zhang, Menghui .

FRONTIERS IN MICROBIOLOGY, 2017, 8

[58] Fecal microbiota transplantation prevents hepatic encephalopathy in rats with carbon tetrachloride-induced acute hepatic dysfunction [J].

Wang, Wei-Wei ;

Zhang, Yu ;

Huang, Xiao-Bing ;

You, Nan ;

Zheng, Lu ;

Li, Jing .

WORLD JOURNAL OF GASTROENTEROLOGY, 2017, 23 (38) :6983-6994

[59] PROFIT, a PROspective, randomised placebo controlled feasibility trial of Faecal mIcrobiota Transplantation in cirrhosis: study protocol for a single-blinded trial [J].

Woodhouse, Charlotte Alexandra ;

Patel, Vishal C. ;

Goldenberg, Simon ;

Sanchez-Fueyo, Alberto ;

China, Louise ;

O'Brien, Alastair ;

Flach, Clare ;

Douiri, Abdel ;

Shawcross, Debbie .

BMJ OPEN, 2019, 9 (02)

[60] Gut microbiota modulate the immune effect against hepatitis B virus infection [J].

Xu, D. ;

Huang, Y. ;

Wang, J. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2015, 34 (11) :2139-2147

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