Endothelial Cell Contributions to COVID-19

被引:15
|
作者
Oxford, Alexandra E. [1 ]
Halla, Fabio [1 ]
Robertson, Evan B. [1 ]
Morrison, Brad E. [1 ,2 ]
机构
[1] Boise State Univ, Dept Biol Sci, Boise, ID 83725 USA
[2] Boise State Univ, Biomol PhD Program, Boise, ID 83725 USA
来源
PATHOGENS | 2020年 / 9卷 / 10期
基金
美国国家卫生研究院;
关键词
COVID-19; coronavirus; SARS-CoV-2; endothelial; vascular; transdifferentiation; exosomes; ACUTE RESPIRATORY SYNDROME; RECEPTOR-BINDING DOMAIN; CORONAVIRUS DISEASE 2019; SPIKE PROTEIN; INFLAMMATION; ACE2; SARS; ACTIVATION; INFECTION; SERINE;
D O I
10.3390/pathogens9100785
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has remained elusive. Coronavirus disease 2019 (COVID-19) caused by this virus has unusual clinical presentation with regard to other related coronaviruses. Recent reports suggest that SARS-CoV-2, unlike other related viruses, infects and replicates within endothelial cells, which may explain a significant portion of the observed clinical pathology. Likewise, mounting evidence associates vascular and endothelial cell dysfunction with increased mortality. This review focuses on understanding how endothelial cell pathology is caused by SARS-CoV-2 at the molecular and cellular levels and how these events relate to COVID-19. A detailed examination of current knowledge regarding canonical inflammatory reaction pathways as well as alteration of endothelial cell-derived exosomes and transdifferentiation by SARS-CoV-2 is included in this assessment. Additionally, given an understanding of endothelial contributions to COVID-19, potential therapeutic aims are discussed, particularly as would affect endothelial function and pathology.
引用
收藏
页码:1 / 14
页数:14
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