Direct and convenient conversion of alcohols to fluorides

被引：92

作者：

Yin, JJ ^{[1
]}

Zarkowsky, DS ^{[1
]}

Thomas, DW ^{[1
]}

Zhao, MM ^{[1
]}

Huffman, MA ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 09期

关键词：

D O I：

10.1021/ol049672a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Directly mixing primary, secondary, and tertiary alcohols with nC(4)F(9)SO(2)F-NR3(HF)(3)-NR3 in THF or MeCN results in convenient conversion to the corresponding fluorides in high yields. The readily available reagents are easy to handle, and the mild, almost neutral reaction conditions allow for excellent functional group compatibility. A NR3(HF)NR3 ratio of less than or equal to1:2 gives the highest reactivity.

引用

页码：1465 / 1468

页数：4

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