Cellular uptake of PNA -: Terpyridine conjugates and its enhancement by Zn2+ ions

被引：31
作者：
Fuessl, Andreas
Schleifenbaum, Andreas
Goeritz, Mareike
Riddell, Andrew
Schultz, Carsten
Kraemer, Roland
机构：
[1] Heidelberg Univ, Inst Anorgan Chem, D-69120 Heidelberg, Germany
[2] European Mol Biol Lab, D-69117 Heidelberg, Germany
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 18期
关键词：
D O I：
10.1021/ja0571139
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+. Copyright © 2006 American Chemical Society.
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收藏
页码：5986 / 5987
页数：2
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