Metabolic and endocrine effects of valproic acid chronic treatment

被引：101

作者：

Belcastro, Vincenzo ^{[1
]}

D'Egidio, Claudia ^{[2
]}

Striano, Pasquale ^{[3
]}

Verrotti, Alberto ^{[4
]}

机构：

[1] St Anna Hosp, Neurol Unit, Dept Neurosci, Como, Italy

[2] Univ G dAnnunzio, Dept Pediat, Chieti, Italy

[3] Univ Genoa, G Gaslini Inst, Pediat Neurol & Muscular Dis Unit, Dept Neurosci Rehabil Ophtalmol Genet Maternal &, Genoa, Italy

[4] Univ Perugia, Dept Pediat, I-06100 Perugia, Italy

来源：

EPILEPSY RESEARCH | 2013年 / 107卷 / 1-2期

关键词：

Valproic acid; Epileptic syndromes; Metabolic syndrome; Atherosclerosis; INTIMA-MEDIA THICKNESS; VASCULAR RISK-FACTORS; FATTY LIVER-DISEASE; ANTIEPILEPTIC DRUGS; WEIGHT-GAIN; EPILEPTIC PATIENTS; SODIUM VALPROATE; SERUM-INSULIN; HOMOCYSTEINE METABOLISM; CARDIOVASCULAR RISK;

D O I：

10.1016/j.eplepsyres.2013.08.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Treatment of epileptic patients with valproic acid (VPA) may be associated with substantial weight changes that may increase morbidity and impair adherence to the treatment regimen. VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resistance, hyperleptinemia and leptin resistance. Patients who gain weight during VPA therapy can develop dyslipidemia and metabolic syndrome that are associated with long-term vascular complications such as hypertension and atherosclerosis. Moreover, an elevation in the levels of uric acid and homocysteine, together with oxidative stress, may contribute to atherosclerotic risk in patients under long-term therapy with VPA. The aim of this review is to discuss the metabolic and endocrine effects of VPA chronic treatment in patients with epilepsy. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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