Anosmia in COVID-19: Mechanisms and Significance

被引：94

作者：

Han, Albert Y. ^{[1
]}

Mukdad, Laith ^{[1
]}

Long, Jennifer L. ^{[1
,2
]}

Lopez, Ivan A. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Head & Neck Surg, 1000 Vet Ave,Rehabil Ctr 35-64, Los Angeles, CA 90095 USA

[2] Greater Los Angeles VA Healthcare Syst, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA

来源：

CHEMICAL SENSES | 2020年 / 45卷 / 06期

关键词：

anosmia; coronavirus; COVID-19; olfaction; postviral anosmia; CENTRAL-NERVOUS-SYSTEM; STOMATITIS-VIRUS INFECTION; MOUSE HEPATITIS-VIRUS; NEURAL STEM-CELLS; OLFACTORY-BULB; SARS CORONAVIRUS; HERPES-SIMPLEX; RECEPTOR; ENCEPHALITIS; DYSFUNCTION;

D O I：

10.1093/chemse/bjaa040

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a challenge for prevention due to asymptomatic or paucisymptomatic patients. Anecdotal and preliminary evidence from multiple institutions shows that these patients present with a sudden onset of anosmia without rhinitis. We aim to review the pathophysiology of anosmia related to viral upper respiratory infections and the prognostic implications. Current evidence suggests that SARS-CoV-2-related anosmia may be a new viral syndrome specific to COVID-19 and can be mediated by intranasal inoculation of SARS-CoV-2 into the olfactory neural circuitry. The clinical course of neuroinvasion of SARS-CoV-2 is yet unclear; however, an extended follow-up of these patients to assess for neurological sequelae, including encephalitis, cerebrovascular accidents, and long-term neurodegenerative risk may be indicated.

引用

页码：423 / 428

页数：6

共 81 条

[61] Intranasal inoculation with the olfactory bulb line variant of mouse hepatitis virus causes extensive destruction of the olfactory bulb and accelerated turnover of neurons in the olfactory epithelium of mice [J].