Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement

被引：163

作者：

Little, Julian ^{[1
,2
]}

Higgins, Julian P. T. ^{[3
]}

Ioannidis, John P. A. ^{[4
,5
]}

Moher, David ^{[1
]}

Gagnon, France ^{[6
]}

von Elm, Erik ^{[7
,8
]}

Khoury, Muin J. ^{[9
]}

Cohen, Barbara ^{[10
]}

Davey-Smith, George ^{[11
]}

Grimshaw, Jeremy ^{[12
]}

Scheet, Paul ^{[13
]}

Gwinn, Marta ^{[9
]}

Williamson, Robin E. ^{[14
]}

Zou, Guang Yong ^{[15
]}

Hutchings, Kim ^{[1
]}

Johnson, Candice Y. ^{[1
]}

Tait, Valerie ^{[1
]}

Wiens, Miriam ^{[1
]}

Golding, Jean ^{[16
]}

van Duijn, Cornelia ^{[17
]}

McLaughlin, John ^{[18
,19
]}

Paterson, Andrew ^{[20
]}

Wells, George ^{[21
]}

Fortier, Isabel ^{[22
,23
]}

Freedman, Matthew ^{[24
]}

Zecevic, Maja ^{[25
]}

King, Richard

Infante-Rivard, Claire ^{[26
]}

Stewart, Alex F. R. ^{[27
]}

Birkett, Nick ^{[1
]}

机构：

[1] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON K1H 8M5, Canada

[2] Canada Res Chair Human Genome Epidemiol, Ottawa, ON, Canada

[3] MRC, Biostat Unit, Cambridge CB2 2BW, England

[4] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece

[5] Tufts Univ, Ctr Genet Epidemiol & Modeling, Sch Med, Boston, MA 02111 USA

[6] Univ Toronto, CIHR New Investigator & Canada Res Chair Epidemio, Dalla Lana Sch Publ Hlth, Toronto, ON M5T 3M7, Canada

[7] Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland

[8] Univ Med Ctr, Dept Med Biometry & Med Informat, German Cochrane Ctr, Freiburg, Germany

[9] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA USA

[10] Publ Lib Sci, San Francisco, CA USA

[11] Univ Bristol, Dept Social Med, MRC, Ctr Causal Anal Translat Epidemiol, Bristol, Avon, England

[12] Univ Ottawa, Dept Med, Canada Res Chair Hlth Knowledge Transfer & Uptake, Clin Epidemiol Program,Ottawa Hlth Res Inst, Ottawa, ON, Canada

[13] Univ Texas Houston, Dept Epidemiol, MD Anderson Canc Ctr, Houston, TX 77030 USA

[14] Amer Journal Human Genet, Boston, MA 02115 USA

[15] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada

[16] Robarts Res Inst, London, ON N6A 5C1, Canada

[17] European Journal Epidemiol, Rotterdam, Netherlands

[18] Canc Care Ontario, Toronto, ON, Canada

[19] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Prosserman Ctr Hlth Res, Toronto, ON M5G 1X5, Canada

[20] Hosp Sick Children, Canada Res Chair Genet Complex Dis, Toronto, ON M5G 1X8, Canada

[21] Univ Ottawa, Inst Heart, Cardiovasc Res Methods Ctr, Ottawa, ON, Canada

[22] McGill Univ, Montreal, PQ H3A 1A4, Canada

[23] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada

[24] Dana Farber Canc Inst, Boston, MA 02115 USA

[25] Lancet, New York, NY USA

[26] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Fac Med, Montreal, PQ, Canada

[27] Univ Ottawa, Inst Heart, Ottawa, ON K1Y 4W7, Canada

来源：

HUMAN GENETICS | 2009年 / 125卷 / 02期

关键词：

Gene-disease associations; Genetics; Gene-environment interaction; Systematic review; Meta-analysis; Reporting recommendations; Epidemiology; Genome-wide association; GENOME-WIDE ASSOCIATION; HARDY-WEINBERG EQUILIBRIUM; SINGLE-NUCLEOTIDE POLYMORPHISM; POPULATION STRATIFICATION; GENOTYPING ERRORS; RANDOMIZED-TRIALS; PROSTATE-CANCER; LARGE-SCALE; DISEASE ASSOCIATIONS; EMPIRICAL-EVALUATION;

D O I：

10.1007/s00439-008-0592-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

引用

页码：131 / 151

页数：21

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