Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions

被引：51
|
作者：
Halimehjani, Azim Ziyaei [2 ]
Pourshojaei, Yaghoub [1 ]
Saidi, Mohammad R. [1 ]
机构：
[1] Sharif Univ Technol, Dept Chem, Tehran 11365, Iran
[2] Tarbiat Moallem Univ, Fac Chem, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 01期
关键词：
ONE-POT SYNTHESIS; SOLID-PHASE SYNTHESIS; N; N'-DISUBSTITUTED THIOUREAS; CONVENIENT METHOD; AMINES; THIOHYDANTOINS; DERIVATIVES; ALKYLATION; MILD;
D O I：
10.1016/j.tetlet.2008.10.063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient and simple synthesis of unsymmetrical thioureas is reported based on the reaction of readily synthesized dithiocarbamates with amines, without using any catalyst under solvent-free conditions. The short reaction time, high yields, and solvent-free conditions are advantages of this method. We did not observe the formation of any symmetric disubstituted thiourea, under these reaction conditions. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：32 / 34
页数：3
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