The biological basis for defining bi-parental or tri-parental origin of offspring from cytoplasmic and spindle transfer

被引：15

作者：

Cohen, Jacques ^{[1
]}

Alikani, Mina ^{[2
]}

机构：

[1] Althea & Tyho Galileo Res Labs, Livingston, NJ 07039 USA

[2] N Shore Univ Hosp, Ctr Human Reprod, Manhasset, NY 11030 USA

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2013年 / 26卷 / 06期

关键词：

bi-parental; definition of parenthood; heteroplasmy; mitochondrial disease; mitochondrial DNA; tri-parental; HUMAN OOCYTES; DNA; EMBRYOS;

D O I：

10.1016/j.rbmo.2013.03.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The bi-parental genetic state is not a given after assisted reproduction. This is based on a biological definition of parentage that concerns generational inheritance of genetic material. Often three or more individuals may participate in artificial reproduction. Only cytoplasmic and spindle transfer can result in the genetic tri-parental state. All other forms involving three or more assisting persons with no heritable genetic contribution must be considered differently. Can a cytoplasmic donor be a biological parent based on a potential contribution of mitochondrial DNA to the offspring? - only if the mitochondrial DNA sequence can be traced back to the donor, a phenomenon which may not be very common. When considering spindle transfer for avoiding transmission of mitochondrial disease, all offspring is likely to be tri-parental. (C) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：535 / 537

页数：3

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