Long-term developmental outcome after early hemispherotomy for hemimegalencephaly in infants with epileptic encephalopathy

被引:64
作者
Honda, Ryoko [1 ]
Kaido, Takanobu [2 ]
Sugai, Kenji [1 ]
Takahashi, Akio [2 ]
Kaneko, Yuu [2 ]
Nakagwa, Eiji [1 ]
Sasaki, Masayuki [1 ]
Otsuki, Taisuke [2 ]
机构
[1] Natl Ctr Neurol & Psychiat, Dept Child Neurol, Tokyo 1878551, Japan
[2] Natl Ctr Neurol & Psychiat, Epilepsy Ctr, Dept Neurosurg, Tokyo 1878551, Japan
关键词
Hemimegalencephaly; Hemispherotomy; Developmental outcome; Seizure outcome; Infant; Epileptic encephalopathy; CATASTROPHIC EPILEPSY; CORTICAL DEVELOPMENT; SURGERY; HEMISPHERECTOMY; CHILDREN; SEIZURE; MALFORMATIONS; COMPLICATIONS; SPASMS;
D O I
10.1016/j.yebeh.2013.06.006
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This study aimed to identify the effect of early hemispherotomy on development in a consecutive series of 12 infants with hemimegalencephaly (HME) demonstrating epileptic encephalopathy. Mean age at onset was 20.4 days (range, 1-140), mean age at surgery was 4.3 months (range, 2-9), and mean follow-up time was 78.8 months (range, 36-121). Eleven patients had a history of early infantile epileptic encephalopathy. Vertical parasagittal hemispherotomy was performed without mortality or severe morbidities. At follow-up, seizure freedom was obtained in 8 patients (66.7%), who showed significantly higher postoperative developmental quotient (DQ) (mean, 31.3; range, 7-61) than those with seizures (mean, 5.5; range, 3-8) (p = 0.02). Within the seizure-free group, postoperative DQ correlated with preoperative seizure duration (r = - 0.811, p = 0.01). Our results showed that shorter seizure duration during early infancy could provide better postoperative DQ in infants with HME and epileptic encephalopathy. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:30 / 35
页数:6
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