A Mechanism-Driven Treatment for Chronic Lymphocytic Leukemia?

被引：17
作者：
Foa, Robin [1 ]
Guarini, Anna [1 ]
机构：
[1] Univ Roma La Sapienza, Dept Hematol, I-00185 Rome, Italy
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 369卷 / 01期
关键词：
TYROSINE KINASE; CELLS;
D O I：
10.1056/NEJMe1303054
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：85 / 87
页数：3
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共 8 条
  • [1] Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies
    Advani, Ranjana H.
    Buggy, Joseph J.
    Sharman, Jeff P.
    Smith, Sonali M.
    Boyd, Thomas E.
    Grant, Barbara
    Kolibaba, Kathryn S.
    Furman, Richard R.
    Rodriguez, Sara
    Chang, Betty Y.
    Sukbuntherng, Juthamas
    Izumi, Raquel
    Hamdy, Ahmed
    Hedrick, Eric
    Fowler, Nathan H.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (01) : 88 - 94
  • [2] Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
    Byrd, John C.
    Furman, Richard R.
    Coutre, Steven E.
    Flinn, Ian W.
    Burger, Jan A.
    Blum, Kristie A.
    Grant, Barbara
    Sharman, Jeff P.
    Coleman, Morton
    Wierda, William G.
    Jones, Jeffrey A.
    Zhao, Weiqiang
    Heerema, Nyla A.
    Johnson, Amy J.
    Sukbuntherng, Juthamas
    Chang, Betty Y.
    Clow, Fong
    Hedrick, Eric
    Buggy, Joseph J.
    James, Danelle F.
    O'Brien, Susan
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (01) : 32 - 42
  • [3] Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
    Contri, A
    Brunati, AM
    Trentin, L
    Cabrelle, A
    Miorin, M
    Cesaro, L
    Pinna, LA
    Zambello, R
    Semenzato, G
    Donella-Deana, A
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) : 369 - 378
  • [4] Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    Duehren-von Minden, Marcus
    Uebelhart, Rudolf
    Schneider, Dunja
    Wossning, Thomas
    Bach, Martina P.
    Buchner, Maike
    Hofmann, Daniel
    Surova, Elena
    Follo, Marie
    Koehler, Fabian
    Wardemann, Hedda
    Zirlik, Katja
    Veelken, Hendrik
    Jumaa, Hassan
    [J]. NATURE, 2012, 489 (7415) : 309 - +
  • [5] BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
    Guarini, Anna
    Chiaretti, Sabina
    Tavolaro, Simona
    Maggio, Roberta
    Peragine, Nadia
    Citarella, Franca
    Ricciardi, Maria Rosaria
    Santangelo, Simona
    Marinelli, Marilisa
    De Propris, Maria Stefania
    Messina, Monica
    Mauro, Francesca Romana
    Del Giudice, Ilaria
    Foa, Robert
    [J]. BLOOD, 2008, 112 (03) : 782 - 792
  • [6] A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi
    Hoogeboom, Robbert
    van Kessel, Kok P. M.
    Hochstenbach, Frans
    Wormhoudt, Thera A.
    Reinten, Roy J. A.
    Wagner, Koen
    Kater, Arnon P.
    Guikema, Jeroen E. J.
    Bende, Richard J.
    van Noesel, Carel J. M.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (01) : 59 - 70
  • [7] Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    Rossi, Davide
    Rasi, Silvia
    Spina, Valeria
    Bruscaggin, Alessio
    Monti, Sara
    Ciardullo, Carmela
    Deambrogi, Clara
    Khiabanian, Hossein
    Serra, Roberto
    Bertoni, Francesco
    Forconi, Francesco
    Laurenti, Luca
    Marasca, Roberto
    Dal-Bo, Michele
    Rossi, Francesca Maria
    Bulian, Pietro
    Nomdedeu, Josep
    Del Poeta, Giovanni
    Gattei, Valter
    Pasqualucci, Laura
    Rabadan, Raul
    Foa, Robin
    Dalla-Favera, Riccardo
    Gaidano, Gianluca
    [J]. BLOOD, 2013, 121 (08) : 1403 - 1412
  • [8] Gene expression profile of protein kinases reveals a distinctive signature in chronic lymphocytic leukemia and in vitro experiments support a role of second generation protein kinase inhibitors
    Tavolaro, Simona
    Chiaretti, Sabina
    Messina, Monica
    Peragine, Nadia
    Del Giudice, Ilaria
    Marinelli, Marilisa
    Santangelo, Simona
    Mauro, Francesca Romana
    Guarini, Anna
    Foa, Robin
    [J]. LEUKEMIA RESEARCH, 2010, 34 (06) : 733 - 741
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